Strain-Release [2π + 2σ] Cycloadditions for the Synthesis of Bicyclo[2.1.1]hexanes Initiated by Energy Transfer

Autor:	Renyu Guo, Yu-Che Chang, Loic Herter, Christophe Salome, Sarah E. Braley, Thomas C. Fessard, M. Kevin Brown
Rok vydání:	2022
Předmět:	Colloid and Surface Chemistry Cycloaddition Reaction Energy Transfer Hexanes General Chemistry Alkenes Biochemistry Article Catalysis
Zdroj:	Journal of the American Chemical Society J Am Chem Soc
ISSN:	1520-5126 0002-7863
Popis:	Saturated bicycles are becoming ever more important in the design and development of new pharmaceuticals. Here a new strategy for the synthesis of bicyclo[2.1.1]hexanes is described. These bicycles are significant because they have defined exit vectors, yet many substitution patterns are underexplored as building blocks. The process involves sensitization of a bicyclo[1.1.0]butane followed by cycloaddition with an alkene. The scope and mechanistic details of the method are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f31c9c56ab2cb2925f3df66cafd75d https://doi.org/10.1021/jacs.2c02976 Zobrazit plný text záznamu