A Simple and Stereospecfic Route to 2,6-Disubstituted 4-Hydroxypiperidines. Synthesis of Dendrobate Alkaloid (+)-241D and Formal Synthesis of (−)-Indolizidine 167B
| Autor: | Haiying Sun, Dawei Ma |
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| Rok vydání: | 2000 |
| Předmět: |
Models
Molecular Chemistry Decarboxylation Organic Chemistry Condensation Indolizines Indolizidine Hydroxylation Dendrobate alkaloid 241D Biochemistry Combinatorial chemistry chemistry.chemical_compound Formal synthesis Enantiopure drug Piperidines Simple (abstract algebra) Organic chemistry Indicators and Reagents Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters. 2:2503-2505 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol006176n |
| Popis: | The condensation of enantiopure beta-amino esters with beta-ketoesters followed by cyclization and decarboxylation afforded 2,3-dihydro-4-pyridones 3, which were selectively hydrogenated to provide 2,6-disubstituted 4-hydroxypiperdines. |
| Databáze: | OpenAIRE |
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