Clinical and MRI correlates of CSF neurofilament light chain levels in relapsing and progressive MS
| Autor: | Raphael P. S. Quintiliano, Adriel S. Moraes, Fernando Cendes, Leonilda M.B. Santos, Benito Pereira Damasceno, Alfredo Damasceno, Alessandro S. Farias, Vinícius O. Boldrini, Verônica Almeida de Paula Galdino da Silva, Carlos Otávio Brandão, Rafael Paternò Castello Dias-Carneiro |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Multiple Sclerosis Neurofilament Neurofilament light Lesion volume Disability Evaluation 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Neurofilament Proteins Recurrence Neuronal damage Image Processing Computer-Assisted medicine Humans Prospective Studies 030212 general & internal medicine Cerebral Cortex Neurologic Examination medicine.diagnostic_test business.industry Multiple sclerosis Magnetic resonance imaging General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Neurology Regression Analysis Biomarker (medicine) Female Neurology (clinical) business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Multiple Sclerosis and Related Disorders. 30:149-153 |
| ISSN: | 2211-0348 |
| DOI: | 10.1016/j.msard.2019.02.004 |
| Popis: | A major aim in MS field has been the search for biomarkers that enable accurate detection of neuronal damage. Besides MRI, recent studies have shown that neuroaxonal damage can also be tracked by neurofilament detection. Nevertheless, before widespread implementation, a better understanding of the principal contributors for this biomarker is of paramount importance. Therefore, we analyzed neurofilament light chain (NfL) in relapsing (RMS) and progressive MS (PMS), addressing which MRI and clinical variables are better related to this biomarker.Forty-seven MS patients underwent MRI (3T) and cerebrospinal fluid (CSF) sampling. We measured NfL concentrations using ELISA (UmanDiagnostics) and performed multivariable regression analysis to assess the contribution of clinical and MRI metrics to NfL.NfL correlated with previous clinical activity in RMS (p 0.001). In RMS, NfL also correlated with Gad+ and cortical lesion volumes. However, after multivariable analysis, only cortical lesions and relapses in previous 12 months remained in the final model (RCSF NfL levels are increased in RMS and associated with relapses and cortical lesions. Although NfL levels were correlated with Gad+ lesion volume, this association did not persist in multivariable analysis after controlling for previous clinical activity. We encourage controlling for previous clinical activity when testing the association of NfL with MRI. In PMS, the major contributor to NfL was T1-hypointense lesion volume. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect