Prostate Cancer Screening in Brazil: a single center experience in the public health system
| Autor: | Gustavo Cardoso Guimarães, Stênio de Cássio Zequi, Ademar Lopes, Renato Almeida Rosa de Oliveira, Thiago Camelo Mourão, Ricardo L. Favaretto, Thiago Borges Marques Santana |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Prostate biopsy Urology Biopsy Population 030232 urology & nephrology Therapeutics urologic and male genital diseases 03 medical and health sciences Prostate cancer 0302 clinical medicine Predictive Value of Tests Internal medicine Epidemiology Medicine Humans Mass Screening education Early Detection of Cancer familial [Supplementary Concept] Aged Retrospective Studies Aged 80 and over education.field_of_study medicine.diagnostic_test business.industry Incidence (epidemiology) Cancer Prostatic Neoplasms Rectal examination Middle Aged Prostate-Specific Antigen medicine.disease Diseases of the genitourinary system. Urology Prostate cancer screening Prostate cance 030220 oncology & carcinogenesis Original Article Public Health RC870-923 business Brazil |
| Zdroj: | International braz j urol, Volume: 47, Issue: 3, Pages: 558-565, Published: 29 MAR 2021 International braz j urol v.47 n.3 2021 International Braz J Urol Sociedade Brasileira de Urologia (SBU) instacron:SBU International Brazilian Journal of Urology, Vol 47, Iss 3, Pp 558-565 (2021) International Brazilian Journal of Urology : official journal of the Brazilian Society of Urology |
| Popis: | Purpose: Incidence and mortality of prostate cancer (PCa) are still increasing in developing countries. Limited access to the health system or more aggressive disease are potential reasons for this. Ethnic and social differences in developed countries seem to make inappropriate to extrapolate data from other centers. We aim to report the epidemiological profile of a PSA-screened population from a cancer center in Brazil. Materials and Methods: We retrospectively selected 9.692 men enrolled in a PCa prevention program, comprising total PSA level and digital rectal examination at the first appointment, associated with complementary tests when necessary. Men aged over 40 years-old were included after shared decision-making process. Prostate biopsy (TRUS) was performed when clinically suspected for PCa. After the diagnosis, patients underwent appropriate treatment. Results: TRUS was performed in 5.5% of men and PCa incidence was 2.6%. Overall ratio between number of patients who needed to be screened in order to diagnose one cancer was 38.9 patients, with 2.1 biopsies performed to diagnose a cancer. Positive predictive value (PPV) of TRUS biopsy in this strategy was 47.2%, varying from 38.5% (80 years-old). We evidenced 70 patients (27.9%) classified as low risk tumors, 74 (29.5%) as intermediate risk, and 107 (42.6%) as high-risk disease. Conclusions: PSA-screening remains controversial in literature. In front of a huge miscegenated people and considering the big proportion of high-risk PCa, even in young men diagnosed with the disease, it is imperative to inform patients and health providers about these data particularities in Brazil. |
| Databáze: | OpenAIRE |
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