Polygenic risk for coronary artery disease in the Scottish and English population
| Autor: | Heribert Schunkert, Matthias Heinig, Fabian Starnecker, Shichao Pang, Ulrich Güldener, Chuhua Yang, Ling Li, Zhifen Chen |
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| Rok vydání: | 2021 |
| Předmět: |
Genetic Markers
Male UK Biobank medicine.medical_specialty Multifactorial Inheritance Population Coronary Artery Disease Polymorphism Single Nucleotide Risk Assessment Coronary artery disease Gene Frequency Internal medicine medicine Prevalence Diseases of the circulatory (Cardiovascular) system Humans Genetic Predisposition to Disease education education.field_of_study Models Genetic business.industry Research Middle Aged medicine.disease Genetic risk score Phenotype England Scotland Heart Disease Risk Factors RC666-701 Cardiology Polygenic risk score Female Genetic Risk Score Uk Biobank business Genome-Wide Association Study |
| Zdroj: | BMC Cardiovascular Disorders BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-9 (2021) BMC Cardiovasc. Disord. 21:586 (2021) |
| ISSN: | 1471-2261 |
| Popis: | Background Epidemiological studies have repeatedly observed a markedly higher risk for coronary artery disease (CAD) in Scotland as compared to England. Up to now, it is unclear whether environmental or genetic factors might explain this phenomenon. Methods Using UK Biobank (UKB) data, we assessed CAD risk, based on the Framingham risk score (FRS) and common genetic variants, to explore the respective contribution to CAD prevalence in Scotland (n = 31,963) and England (n = 317,889). We calculated FRS based on sex, age, body mass index (BMI), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), systolic blood pressure (SBP), antihypertensive medication, smoking status, and diabetes. We determined the allele frequency of published genome-wide significant risk CAD alleles and a weighted genetic risk score (wGRS) for quantifying genetic CAD risk. Results Prevalence of CAD was 16% higher in Scotland as compared to England (8.98% vs. 7.68%, P |
| Databáze: | OpenAIRE |
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