High-Performance Implantable Sensors based on Anisotropic Magnetoresistive La0.67Sr0.33MnO3 for Biomedical Applications
| Autor: | Arturo Vera, Isidoro Martínez, Luiz Guilherme Enger, Bruno Guillet, Rubén Guerrero, José Manuel Diez, Olivier Rousseau, Marc Lam Chok Sing, Victor Pierron, Paolo Perna, Jaime J. Hernández, Isabel Rodríguez, Ivo Calaresu, Anja Meier, Carmen Huck, Ana Domínguez-Bajo, Ankor González-Mayorga, Elisa López-Dolado, María C. Serrano, Laura Ballerini, Lucas Pérez, Rodolfo Miranda, Stéphane Flament, María Teresa González, Laurence Méchin, Julio Camarero |
|---|---|
| Přispěvatelé: | UAM. Departamento de Física de la Materia Condensada, Instituto Imdea Nanociencia, Equipe Electronique - Laboratoire GREYC - UMR6072, Groupe de Recherche en Informatique, Image et Instrumentation de Caen (GREYC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), Scuola Internazionale Superiore di Studi Avanzati / International School for Advanced Studies (SISSA / ISAS), MFD-Diagnostic, Materials Science Factory - ICMM [Madrid], Instituto de Ciencia de Materiales de Madrid (ICMM), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Servicio de Salud de Castilla-La Mancha [Toledo, Spain] (SESCAM), École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU), European Project: 737116,ByAxon |
| Rok vydání: | 2023 |
| Předmět: |
Biomaterials
Magnetic Sensors Neural Interfaces Anisotropic Magnetoresistance In Vitro and in Vivo Biocompatibility Detectivity Measurements anisotropic magnetoresistance magnetic sensors neural interfaces thin film oxide detectivity measurements in vitro and in vivo biocompatibility Biomedical Engineering Thin Film Oxide Física [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics |
| Zdroj: | ACS Biomaterials Science and Engineering ACS Biomaterials Science and Engineering, 2023, 9 (2), pp.1020-1029. ⟨10.1021/acsbiomaterials.2c01147⟩ |
| ISSN: | 2373-9878 |
| DOI: | 10.1021/acsbiomaterials.2c01147 |
| Popis: | Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, los autores pertenecientes a la UAM y el nombre del grupo de colaboración, si lo hubiere We present the design, fabrication, and characterization of an implantable neural interface based on anisotropic magnetoresistive (AMR) magnetic-field sensors that combine reduced size and high performance at body temperature. The sensors are based on La0.67Sr0.33MnO3 (LSMO) as a ferromagnetic material, whose epitaxial growth has been suitably engineered to get uniaxial anisotropy and large AMR output together with low noise even at low frequencies. The performance of LSMO sensors of different film thickness and at different temperatures close to 37 °C has to be explored to find an optimum sensitivity of ∼400%/T (with typical detectivity values of 2 nT·Hz-1/2 at a frequency of 1 Hz and 0.3 nT·Hz-1/2 at 1 kHz), fitted for the detection of low magnetic signals coming from neural activity. Biocompatibility tests of devices consisting of submillimeter-size LSMO sensors coated by a thin poly(dimethyl siloxane) polymeric layer, both in vitro and in vivo, support their high suitability as implantable detectors of low-frequency biological magnetic signals emerging from heterogeneous electrically active tissues |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|