Encapsulation of NIR-II AIEgens in Virus-like Particles for Bioimaging
| Autor: | Fangfang Xia, Weiwei Zhu, Yue Sun, Li Runhao, Xuehong Min, Wei Zhou, Shi-Qi Cheng, Juan Zhang, Ming Li, Feng Li |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Biocompatibility Infrared Rays viruses Nanoparticle Quantum yield Capsules 02 engineering and technology 010402 general chemistry Photochemistry 01 natural sciences Electron Transport Biomimetic Materials In vivo Materials Testing Molecule General Materials Science Optical Imaging Penetration (firestop) 021001 nanoscience & nanotechnology Fluorescence 0104 chemical sciences Viruses Nanoparticles Self-assembly 0210 nano-technology |
| Zdroj: | ACS Applied Materials & Interfaces. 13:17372-17379 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.1c02691 |
| Popis: | The development of organic nanoparticles that fluoresce in the near-infrared, especially in the second near-infrared (NIR-II) window, improves in vivo fluorescence imaging due to deeper penetration and higher spatiotemporal resolution. We report two kinds of NIR-II fluorescent molecules with twisted intramolecular charge-transfer (TICT) and aggregation-induced emission (AIE) characteristics. The virus-like particles (VLPs) of simian virus 40 (SV40) were used as templates to encapsulate the molecules in a well-defined structure (referred to as CH1-SV40 and CH2-SV40). The CH1-SV40 dots exhibited a highly uniform size of 21.5 nm, strong fluorescence, high photostability, and good biocompatibility in vitro and in vivo. Their fluorescence spectrum exhibited a peak at 955 nm, with a tail extending to 1200 nm. Moreover, the CH1-SV40 dots, with a quantum yield of 13.03%, enabled blood vessel imaging and image-guided surgery with a high signal-to-background ratio. Overall, the hybrid nanoparticles represent a new kind of NIR-II AIE nanoprobes for biomedical imaging. |
| Databáze: | OpenAIRE |
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