Correlation between epidermal growth factor receptor tyrosine kinase inhibitor efficacy and circulating tumor cell levels in patients with advanced non-small cell lung cancer
| Autor: | Wen-Jie He, Changlin Tu, Bo Jiang, Li Chang, Wenhui Li, Yunfen Li, Congguo Jin |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty education circulating tumor cells OncoTargets and Therapy Correlation 03 medical and health sciences 0302 clinical medicine Circulating tumor cell EGFR-TKI Internal medicine medicine Pharmacology (medical) In patient Lung cancer neoplasms non-small cell lung cancer Original Research business.industry medicine.disease Confidence interval respiratory tract diseases 030104 developmental biology 030220 oncology & carcinogenesis Non small cell business Tyrosine kinase Epidermal growth factor receptor tyrosine kinase |
| Zdroj: | OncoTargets and therapy |
| ISSN: | 1178-6930 |
| DOI: | 10.2147/ott.s115221 |
| Popis: | Wenjie He,1 Wenhui Li,1 Bo Jiang,1 Li Chang,1 Congguo Jin,2 Changlin Tu,1 Yunfen Li1 1Department of Cadre’s Medical Oncology, Yunnan Tumor Hospital, The Third Affiliated Hospital of Kunming Medical University, 2Department of Oncology Research Institution, Kunming, People’s Republic of China Objective: The aim of this study was to investigate the correlation between the efficacy of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) and circulating tumor cell (CTC) levels in patients with advanced non-small cell lung cancer (NSCLC). The efficacy of EGFR-TKIs in reducing CTC counts in patients with advanced NSCLC was studied.Patients and methods: A total of 66 patients with advanced NSCLC were enrolled and divided into two groups (those with high CTC counts and those with low CTC counts) based on the patients’ median CTC counts. All the patients were treated with an EGFR-TKI, and the treatment efficacy and prognoses were compared.Results: The treatment efficacies were 53.3% (16/30) and 27.8% (10/36) for the low CTC group and high CTC group, respectively, and this difference was statistically significant (P |
| Databáze: | OpenAIRE |
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