Yttrium-90 radiosynovectomy in knees and ankles (25 joints in 22 hemophilic patients). Short-term results
| Autor: | Cláudio Henrique Barbieri, Lauro Wichert-Ana, Luciana Correa Oliveira de Oliveira, Edgard Eduard Engel, Andréa Fernandes Magalhães, Felipe Arriva Pitella |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
musculoskeletal diseases
030204 cardiovascular system & hematology Image analysis 03 medical and health sciences 0302 clinical medicine Magnetic resonance imaging Synovitis Arthropathy Hemarthrosis medicine Immunology and Allergy In patient Prospective cohort study medicine.diagnostic_test business.industry lcsh:RC633-647.5 Hemophilic arthropathy Hematology lcsh:Diseases of the blood and blood-forming organs medicine.disease medicine.anatomical_structure Radiosynoviorthesis Original Article Synovial membrane business Nuclear medicine Body mass index IMAGEM POR RESSONÂNCIA MAGNÉTICA 030215 immunology |
| Zdroj: | Hematology, Transfusion and Cell Therapy, Vol 43, Iss 1, Pp 15-20 (2021) Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Hematology, Transfusion and Cell Therapy, Volume: 43, Issue: 1, Pages: 15-20, Published: 26 MAR 2021 Hematology, Transfusion and Cell Therapy |
| ISSN: | 2531-1379 |
| Popis: | Introduction: The radiosynovectomy (RS) is one treatment option for recurrent hemarthrosis in patients with hemophilia (PWH). A prospective cohort study was designed to evaluate the effects of the RS on the synovial membrane volume in the ankles and knees of PWH and patient characteristics related to the RS outcome. Methods: In a one-year follow-up, 25 joints of 22 PWH who presented 3 bleeds or more in the same joint over the last 6 months (target joints) were subjected to the RS. Two groups were compared: those who retained target joints following the RS and those who did not (less than 3 bleeds/6 months after the RS). The groups were analyzed according to age, hemophilia type/severity, joint, body mass index (BMI), inhibitor and Hemophilia Joint Health Score 2.1 (HJHS). The magnetic resonance images (MRI) of six ankles and six knees were acquired prior to, and 6 months after, the RS. The synovial membrane volume and arthropathy MRI scale were accessed and volumes were compared and correlated with the Yttrium-90 dose injected. Results: Patients with a mean age of 12 years and a mean HJHS of 6.7 (p < 0.05) retained target joints after the RS. The inhibitor, joint, type/severity of disease and BMI showed no significant differences between groups. The synovial membrane volume had a significant reduction after the RS (p = 0.03), but no correlation with the Yttrium-90 dose. In proportion to the synovial membrane volume, doses injected to the ankles were larger than those injected to the knees. Conclusion: The synovial membrane volume is reduced after the RS, regardless of the effective 90Y dose. |
| Databáze: | OpenAIRE |
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