Palmitic acid-modified bovine serum albumin nanoparticles target scavenger receptor-A on activated macrophages to treat rheumatoid arthritis
Autor: | Caifeng Deng, Pei Zhang, Zhirong Zhang, Tao Gong, Ting Gong, Yuan Huang, Haohuan Li, Tiantian Tan |
---|---|
Rok vydání: | 2020 |
Předmět: |
education
Biophysics Palmitic Acid Arthritis Bioengineering 02 engineering and technology Pharmacology Biomaterials Palmitic acid Arthritis Rheumatoid 03 medical and health sciences chemistry.chemical_compound In vivo medicine Animals Chondroitin sulfate Scavenger receptor Bovine serum albumin 030304 developmental biology Receptors Scavenger 0303 health sciences Drug Carriers biology Macrophages technology industry and agriculture Serum Albumin Bovine 021001 nanoscience & nanotechnology medicine.disease In vitro Rats chemistry Mechanics of Materials Celastrol Ceramics and Composites biology.protein Nanoparticles 0210 nano-technology |
Zdroj: | Biomaterials. 258 |
ISSN: | 1878-5905 |
Popis: | Palmitic acid-modified bovine serum albumin (PAB) was synthetized and found to own remarkable scavenger receptor-A (SR-A) targeting ability in vitro and in vivo, through which activated macrophages took up PAB nanoparticles (PAB NPs) 9.10 times more than bovine serum albumin nanoparticles (BSA NPs) and PAB NPs could delivery anti-inflammatory drugs celastrol (CLT) to inflamed tissues more effectively than BSA NPs. Compared with chondroitin sulfate modified BSA NPs targeting activated macrophages via CD44, PAB NPs show a more prominent targeting effect whether in vivo or in vitro. And PAB also demonstrated excellent biosafety compared to maleylated BSA, a known SR-A ligand that was lethal in our study. Furthermore, in adjuvant-induced arthritis rats, CLT-PAB NPs significantly improved disease pathology at a lower CLT dose with high safety, compared with CLT-BSA NPs. In addition, compared with the existing ligands with SR-A targeting due to strong electronegativity, the enhanced electronegativity and introduced PA are both important for the SR-A targeting effect of PAB. Therefore, PAB provides a novel direction for the treatment of rheumatoid arthritis and design of new ligands of SR-A. |
Databáze: | OpenAIRE |
Externí odkaz: |