Busulfan dosing (Q6 or Q24) with adjusted or actual body weight, does it matter?
| Autor: | Sarah C. Evans, David L. DeRemer, Amber B. Clemmons, Farrukh T. Awan |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Cyclophosphamide medicine.medical_treatment Hematopoietic stem cell transplantation Disease-Free Survival Pharmacokinetics medicine Humans Pharmacology (medical) Dosing Antineoplastic Agents Alkylating Busulfan Aged Retrospective Studies business.industry Body Weight Hematopoietic Stem Cell Transplantation Area under the curve Middle Aged Fludarabine Surgery Treatment Outcome Oncology Area Under Curve Hematologic Neoplasms Toxicity Administration Intravenous Female business Immunosuppressive Agents Vidarabine medicine.drug |
| Zdroj: | Journal of Oncology Pharmacy Practice. 21:425-432 |
| ISSN: | 1477-092X 1078-1552 |
| Popis: | Background In hematopoietic stem cell transplantation (HSCT), patients receive individualized treatment planning in conditioning regimens to prevent unwarranted toxicities while maximizing desired outcomes. The dose of a widely studied agent in this setting, busulfan, can be adjusted based on area under the curve (AUC); however, choice of actual body weight (ABW) versus adjusted body weight (DBW) weight to calculate the initial dose may be critical in attaining goal AUC. Objective To determine which weight best correlates with achievement of goal AUC for patients receiving busulfan conditioning for HSCT. Secondary objectives include evaluation of AUC results with clinical outcomes such as toxicity and survival. Methods An institutional review board-approved retrospective analysis was performed on 31 allogeneic HSCT recipients who received intravenous busulfan (Q6H with cyclophosphamide [Bu/Cy] or once daily with fludarabine [Flu/Bu]). Results Eighteen patients received Flu/Bu (50% ABW, 50% DBW) and 13 received Bu/Cy (23% ABW, 77% DBW). Overall, patients dosed by DBW were more likely to undershoot goal AUC (−12.8% vs. +19.5%, p = 0.018) and require dose increases (+20% vs. −19.9%, p = 0.012) versus those dosed by ABW. Subgroup analysis confirmed these results for Bu/Cy (−23.6% vs. +2.2%, p 0.05). No patient experienced busulfan-related toxicity. Conclusions Further prospective studies are warranted to elucidate which weight is most likely to achieve goal AUC and subsequent optimal patient outcomes. |
| Databáze: | OpenAIRE |
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