Conditional expression explains molecular evolution of social genes in a microbe
| Autor: | Christopher R. L. Thompson, Reinaldo Alves de Brito, Atahualpa Castillo Morales, Balint Stewart, Laurence D. Hurst, Nicole Gruenheit, Jennifer Engelmoer, Janaina Lima de Oliveira, Araxi O. Urrutia, Suzanne Battom Brown, Jason B. Wolf |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Science General Physics and Astronomy 02 engineering and technology macromolecular substances Genome General Biochemistry Genetics and Molecular Biology Dictyostelium discoideum Article Evolutionary genetics Evolution Molecular 03 medical and health sciences Negative selection Molecular evolution Conditional expression Dictyostelium 10. No inequality lcsh:Science Gene Genetic diversity Social evolution Multidisciplinary biology fungi General Chemistry 021001 nanoscience & nanotechnology biology.organism_classification 030104 developmental biology Evolutionary biology Microbial Interactions lcsh:Q 0210 nano-technology |
| Zdroj: | Nature Communications Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
| ISSN: | 2041-1723 |
| Popis: | Conflict is thought to play a critical role in the evolution of social interactions by promoting diversity or driving accelerated evolution. However, despite our sophisticated understanding of how conflict shapes social traits, we have limited knowledge of how it impacts molecular evolution across the underlying social genes. Here we address this problem by analyzing the genome-wide impact of social interactions using genome sequences from 67 Dictyostelium discoideum strains. We find that social genes tend to exhibit enhanced polymorphism and accelerated evolution. However, these patterns are not consistent with conflict driven processes, but instead reflect relaxed purifying selection. This pattern is most likely explained by the conditional nature of social interactions, whereby selection on genes expressed only in social interactions is diluted by generations of inactivity. This dilution of selection by inactivity enhances the role of drift, leading to increased polymorphism and accelerated evolution, which we call the Red King process. Genetic diversity in social genes is expected to be shaped by conflict. Here, the authors show that in Dictyostelium discoideum, social genes in fact exhibit diversification patterns consistent with relaxed purifying selection, likely due to their expression only in intermittent social generations. |
| Databáze: | OpenAIRE |
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