Relationship between composition of fatty acid in platelet phospholipid membrane and markers of oxidative stress in healthy men and men after a myocardial infarction
| Autor: | Neda Garjonytė, Algirdas Utkus, Dovilė Karčiauskaitė, Arvydas Kaminskas, Živilė Žymantienė, Vytautas Žėkas, Aldona Baublytė, Inga Bikulčienė, Vaiva Hendrixson, Rėda Matuzevičienė |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Blood Platelets
Male medicine.medical_specialty Myocardial Infarction Phospholipid medicine.disease_cause chemistry.chemical_compound Blood serum Internal medicine medicine Humans Platelet Platelet activation Phospholipids chemistry.chemical_classification business.industry Fatty Acids Fatty acid General Medicine Platelet Activation Malondialdehyde Oxidative Stress Human Study Endocrinology chemistry Cardiovascular Diseases cardiovascular diseases oxidative stress platelet activation business Biomarkers Oxidative stress Polyunsaturated fatty acid |
| Zdroj: | Medical science monitor basic research, Melville : International Scientific Information, Inc, 2021, vol. 27, art. no. e929634, p. [1-12] Medical science monitor basic research, Melville : International Scientific Information, Inc, 2021, vol. 27, e929634, p. [1-12] Medical Science Monitor Basic Research |
| ISSN: | 2325-4416 2325-4394 |
| Popis: | Background: Oxidative stress (OS) is known to be extremely damaging for phospholipids in cell membranes, especially their polyunsaturated fatty acids (PUFAs). OS is known to be associated with increased platelet activation and thrombosis, which lead to cardiovascular lesions. The aim of this study was to investigate how changes in the composition of fatty acids (FAs) in the platelet phospholipid membrane correlate with OS in healthy men and in men who have experienced a myocardial infarction (post-MI men). Material/Methods: FA methyl esters from the platelet phospholipid membrane of 79 apparently healthy and 20 post-MI men were identified using gas chromatography/mass spectrometry. Malondialdehyde (MDA) was measured in the blood serum using high-performance liquid chromatography, and platelet-white blood cell aggregates (PWAs) were analysed based on whole-blood flow cytometry. The composition of platelet membrane FAs was compared to MDA concentration (μg/l) and the percentage of PWA formation between healthy men and individuals who had suffered a myocardial infarction (MI). Results: Statistically, post-MI patients had a significantly higher concentration of blood serum MDA than those in the control group (p=0.000). The level of PUFAs was also higher in the platelet phospholipid membrane of post- MI patients than in healthy individuals (p=0.016). However, the percentage of PWA formation was lower in patients compared with the control group (p |
| Databáze: | OpenAIRE |
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