Approaches to promoting bone marrow mesenchymal stem cell osteogenesis on orthopedic implant surface
| Autor: | Shi-Cheng Huo, Bing Yue |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Histology Review Biofunctionalization Bone tissue Regenerative medicine Bone marrow mesenchymal stem cells Osseointegration Orthopedic implant 03 medical and health sciences 0302 clinical medicine Genetics medicine Molecular Biology Genetics (clinical) business.industry Mesenchymal stem cell technology industry and agriculture Cell Biology equipment and supplies 030104 developmental biology medicine.anatomical_structure Stem cell fate 030220 oncology & carcinogenesis Bone marrow business Biomedical engineering |
| Zdroj: | World Journal of Stem Cells |
| ISSN: | 1948-0210 |
| DOI: | 10.4252/wjsc.v12.i7.545 |
| Popis: | Bone marrow-derived mesenchymal stem cells (BMSCs) play a critical role in the osseointegration of bone and orthopedic implant. However, osseointegration between the Ti-based implants and the surrounding bone tissue must be improved due to titanium's inherent defects. Surface modification stands out as a versatile technique to create instructive biomaterials that can actively direct stem cell fate. Here, we summarize the current approaches to promoting BMSC osteogenesis on the surface of titanium and its alloys. We will highlight the utilization of the unique properties of titanium and its alloys in promoting tissue regeneration, and discuss recent advances in understanding their role in regenerative medicine. We aim to provide a systematic and comprehensive review of approaches to promoting BMSC osteogenesis on the orthopedic implant surface. |
| Databáze: | OpenAIRE |
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