Decreased expression of histamine H1 and H4 receptors suggests disturbance of local regulation in human colorectal tumours by histamine

Autor:	Péter Pócza, Katalin Boér, András Falus, Zsolt Baranyai, Kristóf Dede, Eva Helinger, Pal Demeter, Z. Darvas, Andrea Helinger, Zoltan Pos
Rok vydání:	2008
Předmět:	Adenoma Male medicine.medical_specialty Histology Colorectal cancer Blotting Western Colonic Polyps Down-Regulation Biology Receptors G-Protein-Coupled Pathology and Forensic Medicine Histamine receptor chemistry.chemical_compound Western blot Cell Line Tumor Internal medicine medicine Humans Receptors Histamine H2 Receptors Histamine H1 Intestinal Mucosa Receptor Aged Receptors Histamine H4 medicine.diagnostic_test Rectal Neoplasms Reverse Transcriptase Polymerase Chain Reaction Cell Biology General Medicine Middle Aged medicine.disease Immunohistochemistry Gene Expression Regulation Neoplastic Blot Endocrinology chemistry Colonic Neoplasms Receptors Histamine Female Immunostaining Histamine
Zdroj:	European Journal of Cell Biology. 87:227-236
ISSN:	0171-9335
DOI:	10.1016/j.ejcb.2007.12.003
Popis:	Production of histamine in colon tumours has been described earlier. Histamine-mediated signals have been shown to be implicated in tumour growth, and the effects of histamine are largely determined locally by the histamine receptor expression pattern. We analysed histamine receptor expression in human colorectal cancer, adenoma and normal mucosa by quantitative reverse transcription-polymerase chain reaction (RT-PCR), Western blot analysis and immunostaining. Real-time RT-PCR results revealed significantly decreased (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25df79f6ccdfb517d688b957e76a9692 https://doi.org/10.1016/j.ejcb.2007.12.003 Zobrazit plný text záznamu Full Text from ScienceDirect