Rickets in premature infants fed different formulas
| Autor: | Dorand Rd, Hill Jg, Kulkarni Pb, W. M. Bridger, Montiel Dc, Payne Jh rd |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
Time Factors Vlbw infants Physiology Rickets Infant Premature Diseases Random Allocation medicine Humans Prospective Studies Serum alkaline phosphatase Clinical Trials as Topic business.industry Albumin Infant Newborn Phosphorus General Medicine Infant Low Birth Weight medicine.disease Alkaline Phosphatase Bioavailability Radiography Alkaline phosphatase Female Infant Food High incidence Soybeans Serum phosphorus business Follow-Up Studies |
| Zdroj: | Southern medical journal. 77(1) |
| ISSN: | 0038-4348 |
| Popis: | To study the role of formula as a cause of rickets, we randomly assigned 46 very-low-birth-weight (VLBW) infants (less than or equal to 1,500 gm) to one of three groups receiving either Isomil, a soy isolate formula, Similac with Iron, a common milk-based formula, or Similac 24 LBW, a hypercaloric milk-based formula designed for low-birth-weight infants during the first three to four months of life. Postnatal changes in serum calcium, phosphorus, alkaline phosphatase, and albumin were monitored during this study. Radiologic diagnosis of rickets was made in 60% of infants fed Isomil and 5% fed Similac with Iron. Significantly low levels of serum phosphorus and high levels of serum alkaline phosphatase were also seen in infants fed Isomil. The exact cause of the biochemical changes and the high incidence of rickets among infants fed Isomil is not clear. Poor solubility and possibly the decreased bioavailability of minerals in soy isolate formula may be important. We conclude that rickets occurs with high frequency among VLBW infants fed soy isolate, but not milk-based formulas. We suggest that prolonged feeding of soy isolate formulas should be avoided in VLBW infants. |
| Databáze: | OpenAIRE |
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