Cytogenetic studies in peripheral blood of bovines afflicted by papillomatosis
| Autor: | O. P. Ferraz, Charles Julian Lindsey, N. Diniz, R.C. Stocco, Willy Beçak, Tania Tassinari Rieger, S. R. C. Campos, Thatiana Correa de Melo |
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| Rok vydání: | 2011 |
| Předmět: |
viruses
Lymphocyte Cattle Diseases Papillomatosis Chromosome aberration Asymptomatic Virus Viral Proteins Chromosome instability medicine Animals Bovine papillomavirus Chromosome Aberrations Papilloma General Veterinary biology Chromosome biology.organism_classification DNA-Binding Proteins medicine.anatomical_structure Case-Control Studies Immunology Cattle Female medicine.symptom Brazil |
| Zdroj: | Veterinary and Comparative Oncology. 9:269-274 |
| ISSN: | 1476-5810 |
| DOI: | 10.1111/j.1476-5829.2011.00263.x |
| Popis: | Ten types of bovine papillomavirus (BPV) have been described and there are reports of viral transmission via blood. The presence of viral DNA in lymphocytes was described to be associated with chromosome instability in these cells. This study presents an evaluation of chromosome instability in short-term peripheral lymphocyte cultures from cows presenting skin papillomatosis, compared with asymptomatic infected animals and non-infected healthy bovines. In a total of 2203 cells, 918 (42%) showed at least one chromosome aberration: 42.7 (± 7.8) in animals with papillomatosis (BPV + W), 40.2 (± 11) in asymptomatic animals (BPV-W) and 4 (± 2) in control animals. Significant differences were found between the infected group (with or without symptoms) and the control group (P < 0.0001). The increased frequencies of chromosome aberrations suggest an interaction between the virus and host cell chromatin. |
| Databáze: | OpenAIRE |
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