Association of inflammatory response and oxidative injury in the pathogenesis of liver steatosis and insulin resistance following subchronic exposure to malathion in rats
| Autor: | Alya Annabi, Ines Bini Dhouib, Nadia Belhadjhmida, Aicha Jrad Lamine, Najoua Gharbi, Jaouida Abdelmoula, Saloua El Fazaa, Kahna Bouzid, Malika Ben Ahmed, Mohamed Montassar Lasram |
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| Rok vydání: | 2013 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Maximum Tolerated Dose Health Toxicology and Mutagenesis medicine.medical_treatment Inflammation Type 2 diabetes Biology Toxicology medicine.disease_cause Insulin resistance Internal medicine medicine Glucose homeostasis Animals Pesticides Rats Wistar Pharmacology Liver injury Insulin General Medicine medicine.disease Rats Fatty Liver Oxidative Stress Endocrinology Gene Expression Regulation Toxicity Malathion Cytokines Lipid Peroxidation medicine.symptom Chemical and Drug Induced Liver Injury Insulin Resistance Oxidative stress Biomarkers |
| Zdroj: | Environmental toxicology and pharmacology. 38(2) |
| ISSN: | 1872-7077 |
| Popis: | Insulin resistance and risk of type 2 diabetes are the most important complications following exposure to organophosphorous (OPs) pesticides. Regarding the importance of liver on metabolic pathways regulation, in particular blood glucose homeostasis, we focused on liver inflammation and oxidative damages in a subchronic model of toxicity by malathion. Adult male Wistar rats of body weight 200-250g were used for the study. Malathion (200mg/kg b.w./day) was administered to rats by oral intubation for 28 days. Glycemic and insulin resistance indices, markers of liver injury, markers of inflammation and oxidative stress were assessed. Malathion-treated rats showed increased glycemia, insulinemia and glycated hemoglobin level, HOMA-IR and HOMA-β indices, plasma activities of hepatocellular enzymes, lipid peroxidation index, CD3(+)/CD4(+) and CD3(+)/CD4(+) and pro-inflammatory cytokines when decreased antioxidant status in liver was noted. Most of our study indicates that malathion promotes insulin resistance, inflammation and Hepatosteatosis in subchronic model of exposure. On the basis of biochemical and molecular findings, it is concluded that insulin resistance induced by malathion occurs through oxidative stress and related pro-inflammatory markers in a way to result in a reduced function of insulin in liver cells. |
| Databáze: | OpenAIRE |
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