Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis

Autor: Wechsler, M.E., Akuthota, Praveen, Jayne, David R.W.David, Khoury, Paneez, Klion, Amy, Langford, Carol A, Merkel, Peter PA, Moosig, Frank, Specks, Ulrich, Cid, Maria MC, Luqmani, Raashid, Brown, Judith, Mallett, Stephen, Philipson, Richard, Yancey, Steve SW, Steinfeld, Jonathan, Weller, Peter F, Gleich, Gerald J, EGPA Mepolizumab Study Team, Roufosse, Florence
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Adult
Male
medicine.medical_specialty
Injections
Subcutaneous
Churg-Strauss Syndrome
Placebo
Antibodies
Monoclonal
Humanized
Gastroenterology
Article
Disease-Free Survival
03 medical and health sciences
Leukocyte Count
0302 clinical medicine
Double-Blind Method
Prednisone
Recurrence
Internal medicine
Eosinophilic
medicine
Immunologic Factors
Humans
Churg-Strauss Syndrome -- drug therapy -- immunology
Glucocorticoids
030203 arthritis & rheumatology
Intention-to-treat analysis
business.industry
Remission Induction
Granulomatosis with Polyangiitis
General Medicine
respiratory system
Sciences bio-médicales et agricoles
Middle Aged
medicine.disease
Glucocorticoids -- therapeutic use
Surgery
Injections
Subcutaneous -- adverse effects
Intention to Treat Analysis
Eosinophils
Immunologic Factors -- adverse effects -- therapeutic use
030228 respiratory system
Prednisolone
Drug Therapy
Combination
Female
Eosinophilic vasculitis
Antibodies
Monoclonal
Humanized -- adverse effects -- therapeutic use
Granulomatosis with polyangiitis
business
Mepolizumab
medicine.drug
Zdroj: The New England journal of medicine, 376 (20
Popis: Eosinophilic granulomatosis with polyangiitis is an eosinophilic vasculitis. Mepolizumab, an anti-interleukin-5 monoclonal antibody, reduces blood eosinophil counts and may have value in the treatment of eosinophilic granulomatosis with polyangiitis.
0
info:eu-repo/semantics/published
Databáze: OpenAIRE
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