Effects of enzyme induction on metabolism of prednisolone. Clinical and laboratory study
| Autor: | Peter Brooks, W W Downie, W. Watson Buchanan, M Grove |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Adult
Prednisolone Immunology Pharmacology General Biochemistry Genetics and Molecular Biology Arthritis Rheumatoid Pharmacotherapy Rheumatology medicine Humans Immunology and Allergy Drug Interactions Enzyme inducer Aged biology business.industry Half-life Metabolism Middle Aged medicine.disease 11-Hydroxycorticosteroids Enzyme Induction Phenobarbital Rheumatoid arthritis Microsomes Liver biology.protein Cosyntropin business Drug metabolism Half-Life Research Article medicine.drug |
| Zdroj: | Annals of the Rheumatic Diseases. 35:339-343 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.35.4.339 |
| Popis: | The addition of phenobarbitone in therapeutic dosage to the drug regimen of prednisolone-treated subjects with rheumatoid arthritis produced measurable deterioration in the clinical status of the patients associated with a more rapid clearance of prednisolone from plasma. It is considered that phenobarbitone induced the hepatic metabolism of prednisolone, effectively reducing the steady state plasma level and resulting in clinical relapse. A slight but significant improvement in the adrenocortical response to tetracosactrin (Synacthen) was noted after phenobarbitone therapy. |
| Databáze: | OpenAIRE |
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