Restoration of motor control and dopaminergic activity in rats with unilateral 6-hydroxy-dopamine lesions - Retracted
| Autor: | Paul L. J. Tan, Stephen J. M. Skinner, Thorsten Gorba, Hai Lin, Robert B. Elliott, Marilyn S. Geaney |
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| Rok vydání: | 2011 |
| Předmět: |
Embryology
medicine.medical_specialty Tyrosine 3-Monooxygenase Cell Transplantation Sus scrofa Biomedical Engineering Striatum Motor Activity Lesion chemistry.chemical_compound Implants Experimental Internal medicine medicine Animals Oxidopamine Behavior Animal business.industry Regeneration (biology) Dopaminergic Motor control Recovery of Function Immunohistochemistry Rats Neostriatum Endocrinology chemistry Anesthesia Choroid Plexus Choroid plexus medicine.symptom business |
| Zdroj: | Regenerative Medicine. 6:319-326 |
| ISSN: | 1746-076X 1746-0751 |
| DOI: | 10.2217/rme.11.15 |
| Popis: | AIM To restore motor function and dopaminergic activity in the nigrostriatum of rats with unilateral 6-hydroxy-dopamine lesions using implants of encapsulated porcine choroid plexus cells. MATERIALS & METHODS Neonatal porcine choroid plexus cells were prepared and maintained in culture, then encapsulated within alginate-polyornithine capsules (600-660 µm). Rats were unilaterally injected with 6-hydroxy-dopamine into the striatum. Those with lesions verified after 2 and 4 weeks were selected for experiments. Rats were implanted adjacent to the lesion with ten capsules 2-4 days later with (treated, n = 12) or without (control, n = 10) choroid plexus cells. RESULTS The choroid plexus cells were shown to produce a wide range of neurorestorative proteins. The treated group had a 60% improvement in motor behavior compared with the control group (p < 0.01). The treated group also had a significant improvement in nigrostriatal dopaminergic activity (31%, p < 0.02). CONCLUSION Capsules containing porcine choroid plexus cells release therapeutic molecules that stimulate regeneration of the lesioned nigrostriatum in rats. |
| Databáze: | OpenAIRE |
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