In Silico Identification of a Potent Arsenic Based Approved Drug Darinaparsin against SARS-CoV-2: Inhibitor of RNA dependent RNA polymerase (RdRp) and Necessary Proteases

Autor:	Gourisankar Roymahapatra, Santi M. Mandal, Trinath Chowdhury
Rok vydání:	2020
Předmět:	Proteases biology Chemistry viruses In silico Endoribonuclease RNA-dependent RNA polymerase Active site medicine.disease_cause Approved drug Biochemistry medicine biology.protein Darinaparsin Coronavirus
DOI:	10.26434/chemrxiv.12200495.v1
Popis:	The work demonstrate screening of several arsenical compounds against RdRp of coronavirus. The study implies out of all arsenical compounds, darinaparsin shows its most effective results based on in silico docking analysis. This study also confirmed the significant interaction between the active site of viral replicase protein, endoribonuclease protein and different proteases with darinaparsin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d738e4eb93ee7b35708b9d26db6a13 https://doi.org/10.26434/chemrxiv.12200495.v1 Zobrazit plný text záznamu