Erythromycin gastrokinetic activity is partially vagally mediated

Autor: C. Mathis, Charles-Henri Malbert
Přispěvatelé: Station de recherches porcines, Institut National de la Recherche Agronomique (INRA)
Jazyk: angličtina
Rok vydání: 1998
Předmět:
Time Factors
Physiology
Swine
genre humain
motiline
Pharmacology
Vagotomy
modèle
Parasympathetic nervous system
0302 clinical medicine
VIDANGE STOMACALE
NERF PNEUMOGASTRIQUE
Pyloric Antrum
Infusions
Intravenous
motricité gastrointestinale
Stomach
digestive
oral
and skin physiology
Gastroenterology
Vagus Nerve
3. Good health
Erythromycin
medicine.anatomical_structure
030220 oncology & carcinogenesis
érythromycine
030211 gastroenterology & hepatology
Female
medicine.drug
medicine.medical_specialty
Duodenum
Médecine humaine et pathologie
Biology
Motilin
03 medical and health sciences
Physiology (medical)
Internal medicine
medicine
Animals
porcin
pylore
Hepatology
Gastric emptying
Muscle
Smooth
Pylorus
Vagus nerve
Autonomic nervous system
Endocrinology
Gastric Emptying
Human health and pathology
Gastrointestinal Motility
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Zdroj: AJP-Gastrointestinal and Liver Physiology
AJP-Gastrointestinal and Liver Physiology, American Physiological Society, 1998, 274 (1), pp.G80-G86
American Journal of Physiology. Gastrointestinal and Liver Physiology 1 (274), G80-G86. (1998)
ISSN: 0193-1857
1522-1547
Popis: Erythromycin overcomes postvagotomy gastroparesia in patients without a distal stomach and functional pylorus. We investigate the role of the vagus in gastric emptying increased by erythromycin, using a model that preserves the physiology of the distal stomach and pylorus. The effects of erythromycin lactobionate (10 mg/kg) on transpyloric flow pattern and pyloric resistance were evaluated during repetitive bilateral vagal cooling in anesthetized pigs. Vagal cooling during erythromycin infusion produced a marked decreased of pyloric outflow (23 ± 1.1 vs. 50 ± 2.6 ml/min) related to a reduced stroke volume of the flow pulses (7.8 ± 3.31 vs. 14.1 ± 2.44 ml). The amplitude and frequency of gastric and duodenal pressure events were unchanged or slightly reduced during vagal cooling. The smaller stroke volume of flow pulse was the consequence of increased pyloric resistance (6.2 ± 1.98 vs. 2.3 ± 0.21 mmHg ⋅ ml−1 ⋅ s), which is associated with changes in the temporal relationship between a pyloric pressure event and flow pulse. In conclusion, erythromycin activity on the pylorus requires the integrity of vagal pathways. Enhancement of gastric outflow by erythromycin is also modulated by the vagus, since pyloric resistance was able to overcome increased gastric motility.
Databáze: OpenAIRE
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