Erythromycin gastrokinetic activity is partially vagally mediated
Autor: | C. Mathis, Charles-Henri Malbert |
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Přispěvatelé: | Station de recherches porcines, Institut National de la Recherche Agronomique (INRA) |
Jazyk: | angličtina |
Rok vydání: | 1998 |
Předmět: |
Time Factors
Physiology Swine genre humain motiline Pharmacology Vagotomy modèle Parasympathetic nervous system 0302 clinical medicine VIDANGE STOMACALE NERF PNEUMOGASTRIQUE Pyloric Antrum Infusions Intravenous motricité gastrointestinale Stomach digestive oral and skin physiology Gastroenterology Vagus Nerve 3. Good health Erythromycin medicine.anatomical_structure 030220 oncology & carcinogenesis érythromycine 030211 gastroenterology & hepatology Female medicine.drug medicine.medical_specialty Duodenum Médecine humaine et pathologie Biology Motilin 03 medical and health sciences Physiology (medical) Internal medicine medicine Animals porcin pylore Hepatology Gastric emptying Muscle Smooth Pylorus Vagus nerve Autonomic nervous system Endocrinology Gastric Emptying Human health and pathology Gastrointestinal Motility [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
Zdroj: | AJP-Gastrointestinal and Liver Physiology AJP-Gastrointestinal and Liver Physiology, American Physiological Society, 1998, 274 (1), pp.G80-G86 American Journal of Physiology. Gastrointestinal and Liver Physiology 1 (274), G80-G86. (1998) |
ISSN: | 0193-1857 1522-1547 |
Popis: | Erythromycin overcomes postvagotomy gastroparesia in patients without a distal stomach and functional pylorus. We investigate the role of the vagus in gastric emptying increased by erythromycin, using a model that preserves the physiology of the distal stomach and pylorus. The effects of erythromycin lactobionate (10 mg/kg) on transpyloric flow pattern and pyloric resistance were evaluated during repetitive bilateral vagal cooling in anesthetized pigs. Vagal cooling during erythromycin infusion produced a marked decreased of pyloric outflow (23 ± 1.1 vs. 50 ± 2.6 ml/min) related to a reduced stroke volume of the flow pulses (7.8 ± 3.31 vs. 14.1 ± 2.44 ml). The amplitude and frequency of gastric and duodenal pressure events were unchanged or slightly reduced during vagal cooling. The smaller stroke volume of flow pulse was the consequence of increased pyloric resistance (6.2 ± 1.98 vs. 2.3 ± 0.21 mmHg ⋅ ml−1 ⋅ s), which is associated with changes in the temporal relationship between a pyloric pressure event and flow pulse. In conclusion, erythromycin activity on the pylorus requires the integrity of vagal pathways. Enhancement of gastric outflow by erythromycin is also modulated by the vagus, since pyloric resistance was able to overcome increased gastric motility. |
Databáze: | OpenAIRE |
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