Risk and short-term prognosis of myocardial infarction among users of antidiabetic drugs
| Autor: | Joseph K. McLaughlin, Henriette Thisted, Henrik Toft Sørensen, Søren Paaske Johnsen, Mette Lena Olsen, Tbm Monster, H.H. Lervang, Jørgen Rungby |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Denmark Population Myocardial Infarction Pharmacology Lower risk Drug Prescriptions Risk Assessment Pharmacotherapy Internal medicine Case fatality rate medicine Confidence Intervals Odds Ratio Humans Hypoglycemic Agents Insulin Pharmacology (medical) education Aged Aged 80 and over education.field_of_study business.industry Case-control study General Medicine Odds ratio Middle Aged Prognosis Confidence interval Hospitalization Sulfonylurea Compounds Case-Control Studies Female Risk assessment business Follow-Up Studies |
| Zdroj: | Thisted, H, Johnsen, S P, Monster, TBM, Olsen, ML, McLaughlin, JK, Sørensen, H T, Lervang, H H & J., R 2007, ' Risk and short-term prognosis of myocardial infarction among users of antidiabetic drugs ', 41 st annual meeting of the Scandinavian Society for the Study of Diabetes, Rejkavik, Iceland, 26/05/2006-27/05/2006 . Aarhus University Johnsen, S P, Monster, TBM, Olsen, M L, Thisted, H, McLaughlin, JK, Sørensen, H T, Lervang, H H & J., R 2006, ' Risk and short-term prognosis of myocardial infarction among users of antidiabetic drugs ', American Journal of Therapeutics, vol. 13, pp. 134-40 . |
| Popis: | Old sulphonylureas have been linked with adverse cardiovascular effects; however, data on the clinical implications are sparse. We examined the association between use of sulphonylureas and other antidiabetic drugs and the risk and case fatality rate (CFR) of myocardial infarction (MI) in a population-based case-control and follow-up study, respectively. A total of 6738 cases of first-time MI and 67,374 age- and gender-matched population controls were identified from the Hospital Discharge Registry and the Civil Registration System of North Jutland County, Denmark, in the period 1994 through 2002. Prescriptions for antidiabetic drugs before the index date were retrieved from a prescription database. We estimated odds ratios (ORs) of MI (case-control study) and 30-day CFR (follow-up study) associated with antidiabetic drug use adjusted for possible confounding factors and using nondiabetic subjects as the reference group. The risk of MI appeared higher among users of old sulphonylureas (adjusted OR, 2.07; 95% confidence interval (CI), 1.81-2.37) than among users of new sulphonylureas (adjusted OR, 1.36; 95% CI, 1.01-1.84). The adjusted ORs among users of nonsulphonylurea oral antidiabetic drugs, insulin, and patients with diabetes not receiving pharmacotherapy were 1.38 (95% CI, 0.90-2.11), 2.56 (95% CI, 2.16-3.03), and 3.51 (95% CI, 2.92-4.22), respectively. The overall 30-day CFR was 24.6%, but varied between 9.5% and 37.0% among the different categories. New sulphonylureas may be associated with a lower risk of MI than old sulphonylureas. Furthermore, the 30-day CFR may vary according to type of antidiabetic drug. These differences indicate the need for further examination of the cardiovascular safety of antidiabetic drugs. |
| Databáze: | OpenAIRE |
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