| Popis: |
The effects of stem bark extracts of Parkia biglobosa on haematological parameters of West African Dwraf (WAD) goats averagely weigh 10kg was investigated. The plant was sourced from Tsaragi community in Edu LGA, Kwara State, Nigeria and extracted with methanol to yield crude methanol stem bark extract (CMSBE). This CMSBE was partitioned with n- Hexane, ethyl acetate and water to yield additional ethyl acetate (EA) fraction and aqueous (AQ) fraction. The haematological parameters evaluation were carried out in 18 WAD goats infected with Haemonchus contortus in six groups of completely block design at three animals per group. Group A and B were dosed with 5mL/kg of distilled water and 6.25mg/kg of Albendazole (ABZ) for negative and positive control respectively. Groups C and D with 1000mg/kg and 2000mg/kg of CMSBE respectively and groups E and F with 1000mg/kg of EA fraction and AQ fraction each respectively. The haematological parameters evaluated were Parked cell volume (PCV), haemoglobin concentration (Hb), total red blood cell (TRBC), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) and differential white blood cell count such as neutrophils, lymphocytes and monocytes, eosinophils, neutrophils and basophils. The results showed that CMSBE, EA fraction and AQ fraction have no significant (P>0.05) effect on haematological paremeters of WAD goats based on the doses used. However, the increase in Hb, RBC and PCV observed in this study suggested that P. biglobosa extracts may be pursued for their clinical relevance in the management of anaemia and in treatment of infectious disease caused by helminth parasites like H. contortus. It is therefore, recommended to establish a baseline indices for haematological parameters on the basis of factors such as sex, age, breed, and nutrition of animals and carry out further studies to determine the effects of these factors on these indices. |
