PONV management in patients with QTc prolongation on the EKG
| Autor: | W Ackermann, Suren Soghomonyan, Nicoleta Stoicea, S P Bhandary |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
QTC PROLONGATION
medicine.medical_specialty Mini Review perioperative period postoperative nausea and vomiting 030204 cardiovascular system & hematology anesthesia 030226 pharmacology & pharmacy QT interval 03 medical and health sciences 0302 clinical medicine QTc medicine Repolarization In patient Pharmacology (medical) cardiovascular diseases Prospective cohort study Intensive care medicine Pharmacology business.industry lcsh:RM1-950 PONV Perioperative lcsh:Therapeutics. Pharmacology Increased risk cardiovascular system torsade de pointes medicine.symptom business Postoperative nausea and vomiting |
| Zdroj: | Frontiers in Pharmacology Frontiers in Pharmacology, Vol 11 (2021) |
| ISSN: | 1663-9812 |
| Popis: | Postoperative nausea and vomiting (PONV) is a commonly encountered problem in surgical practice. It delays discharge from the post-anesthesia care unit, requires additional resources to treat, and may increase the morbidity in some patients. Many effective drugs are available to treat or prevent PONV, however many of these drugs have the potential to prolong the QTc on the electrocardiogram (EKG) and increase the risk of serious ventricular arrhythmias, in particular, torsade de pointes. The QTc prolongation may be a manifestation of a genetic mutation resulting in abnormal myocyte repolarization or it may be acquired and associated with the use of various medications, electrolyte disorders, and physiological conditions. Patients predisposed to QTc prolongation presenting for surgery constitute a challenging group, since many drugs commonly used for PONV management will put them at risk for perioperative serious arrhythmias. This is an important topic, and our mini-review is an attempt to highlight the problem, summarize the existing experience, and generate recommendations for safe management of PONV for patients, who are at increased risk of QTc prolongation and arrhythmias. Focused prospective studies will help to find definitive answers to the discussed problems and challenges and develop specific guidelines for clinical application. |
| Databáze: | OpenAIRE |
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