Differential roles for Nr4a1 and Nr4a2 in object location vs. object recognition long-term memory
Autor: | Ruth M. Barrett, M. Felicia Davatolhagh, Dina P. Matheos, Marcelo A. Wood, Susan E. McNulty, Annie Vogel-Ciernia, Aaron J. Schiffman, Nicole S. Hernandez, Melissa Malvaez |
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Rok vydání: | 2012 |
Předmět: |
Male
Memory Long-Term Time Factors genetic structures Computer science Cognitive Neuroscience media_common.quotation_subject Hippocampal formation Brief Communication Hippocampus Mice Cellular and Molecular Neuroscience Form perception Nuclear Receptor Subfamily 4 Group A Member 2 Perirhinal cortex Nuclear Receptor Subfamily 4 Group A Member 1 medicine Animals Learning Contrast (vision) RNA Messenger RNA Small Interfering media_common Cerebral Cortex Neurons Long-term memory Cognitive neuroscience of visual object recognition Recognition Psychology Object (computer science) Expression (mathematics) Mice Inbred C57BL Neuropsychology and Physiological Psychology medicine.anatomical_structure Gene Expression Regulation Phosphopyruvate Hydratase Neuroscience |
Zdroj: | Learning & Memory. 19:588-592 |
ISSN: | 1549-5485 |
Popis: | Nr4a1 and Nr4a2 are transcription factors and immediate early genes belonging to the nuclear receptor Nr4a family. In this study, we examine their role in long-term memory formation for object location and object recognition. Using siRNA to block expression of either Nr4a1 or Nr4a2, we found that Nr4a2 is necessary for both long-term memory for object location and object recognition. In contrast, Nr4a1 appears to be necessary only for object location. Indeed, their roles in these different types of long-term memory may be dependent on their expression in the brain, as NR4A2 was found to be expressed in hippocampal neurons (associated with object location memory) as well as in the insular and perirhinal cortex (associated with object recognition memory), whereas NR4A1 showed minimal neuronal expression in these cortical areas. These results begin to elucidate how NR4A1 and NR4A2 differentially contribute to object location versus object recognition memory. |
Databáze: | OpenAIRE |
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