Protective Role of C-Phycocyanin Against Secondary Changes During Sodium Selenite Mediated Cataractogenesis
| Autor: | Rasiah Pratheepa Kumari, Kumarasamy Anbarasu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
chemistry.chemical_element Plant Science Toxicology medicine.disease_cause Cyanobacteria Biochemistry Cataract Analytical Chemistry Superoxide dismutase chemistry.chemical_compound Internal medicine medicine Sodium selenite Pharmacology Kidney biology business.industry Organic Chemistry Glutathione C-phycocyanin Endocrinology medicine.anatomical_structure chemistry Catalase Toxicity biology.protein Original Article Age-related cataract business Oxidative stress Selenium Cataractogenesis Food Science |
| Zdroj: | Natural Products and Bioprospecting |
| ISSN: | 2192-2209 2192-2195 |
| Popis: | Age related cataract is the leading cause of blindness associated with accumulation of oxidative stress in the eye lens. The present investigation reveals the rational of the beneficial effects of the natural compound C-phycocyanin (C-PC) is beneficial when administered to rat pups to protect against the secondary effects of sodium selenite induced cataractogenesis. A single subcutaneous dose of sodium selenite (19 μmol/kg body weight) on the 10th day of postpartum is adequate to induce cataract in rat pups. Serum biochemical parameters, such as the level of electrolytes, mean activities of anti-oxidant enzymes i.e. superoxide dismutase, catalase and reduced glutathione were observed to be significantly altered during selenite induced cataractogenic process. Histopathological examination revealed signs of degradation of normal cell architecture in the liver, kidney and eye lens. Interestingly, the deleterious effects of sodium selenite toxicity were restored with the simultaneous treatment with C-PC. The results suggest that an administration of 200 mg/kg body weight of C-PC has the ability to prevent/alter the secondary changes reflected in the serum biochemical and histological modifications in rats exposed to sodium selenite. These results complement the beneficial role of C-PC of cyanobacterial origin as a efficacious anti-cataractogenic agent against sodium selenite toxicity. |
| Databáze: | OpenAIRE |
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