Minimal transmission in an influenza A (H3N2) human challenge-transmission model within a controlled exposure environment
| Autor: | Nguyen-Van-Tam, Jonathan S., Killingley, Ben, Enstone, Joanne, Hewitt, Michael, Pantelic, Jovan, Grantham, Michael L., Bueno de Mesquita, P. Jacob, Lambkin-Williams, Robert, Gilbert, Anthony, Mann, Alexander, Forni, John, Noakes, Catherine J., Levine, Min Z., Berman, LaShondra, Lindstrom, Stephen, Cauchemez, Simon, Bischoff, Werner, Tellier, Raymond, Milton, Donald K., for the EMIT Consortium |
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| Přispěvatelé: | Palese, Peter, University of Nottingham, UK (UON), University of Maryland [College Park], University of Maryland System, hVIVO [London], University of Leeds, Centers for Disease Control and Prevention [Atlanta] (CDC), Centers for Disease Control and Prevention, Imperial College London, Modélisation mathématique des maladies infectieuses - Mathematical modelling of Infectious Diseases, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Wake Forest School of Medicine [Winston-Salem], Wake Forest Baptist Medical Center, McGill University = Université McGill [Montréal, Canada], This work was supported by U.S. CDC, Cooperative Agreement: Grant Number 1U01P000497-01. This work was also supported by the National Institute of Allergy and Infectious Diseases Centers of Excellence for Influenza Research and Surveillance (CEIRS)., EMIT Consortium Team Members : Walt Adamson, Blanca Beato-Arribas, Werner Bischoff, William Booth, Simon Cauchemez, Sheryl Ehrman, Joanne Enstone, Neil Ferguson, John Forni, Anthony Gilbert, Michael Grantham, Lisa Grohskopf, Andrew Hayward, Michael Hewitt, Ashley Kang, Ben Killingley, Robert Lambkin-Williams, Alex Mann, Donald Milton, Jonathan Nguyen-Van-Tam, Catherine Noakes, John Oxford, Massimo Palmarini, Jovan Pantelic, and Jennifer Wang. The Scientific Advisory Board members were: Allan Bennett, Ben Cowling, Arnold Monto, and Raymond Tellier. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
RNA viruses Face shield Viral Diseases Influenza Viruses Atmospheric Science business.product_category Pulmonology Fevers Pathology and Laboratory Medicine medicine.disease_cause Serology law.invention MESH: Aerosols Medical Conditions Randomized controlled trial [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST] law Pandemic Influenza A Virus Medicine and Health Sciences Influenza A virus Medicine Infection control Transmission risks and rates Biology (General) Materials Volunteer 0303 health sciences MESH: Influenza Human 030302 biochemistry & molecular biology 3. Good health Infectious Diseases Transmission (mechanics) Medical Microbiology Viral Pathogens H3N2 Subtype Physical Sciences Viruses Pneumonia & Influenza Female Pathogens Infection Human Research Article medicine.medical_specialty QH301-705.5 EMIT Consortium Materials Science Immunology Environment controlled MESH: Influenza A Virus H3N2 Subtype Microbiology Respiratory Disorders 03 medical and health sciences Meteorology Signs and Symptoms Clinical Research Large droplet Internal medicine Virology Influenza Human Genetics Humans Microbial Pathogens Molecular Biology 030304 developmental biology Aerosols SARS MESH: Humans Biology and life sciences 030306 microbiology business.industry Prevention Influenza A Virus H3N2 Subtype Organisms Humidity Influenza a RC581-607 MESH: Male Influenza Emerging Infectious Diseases Mixtures Respiratory Infections Earth Sciences Parasitology Immunologic diseases. Allergy Clinical Medicine business MESH: Female Orthomyxoviruses |
| Zdroj: | PLoS Pathogens PLoS Pathogens, 2020, 16 (7), pp.e1008704. ⟨10.1371/journal.ppat.1008704⟩ PLoS Pathogens, Vol 16, Iss 7, p e1008704 (2020) PLoS Pathogens, Public Library of Science, 2020, 16 (7), pp.e1008704. ⟨10.1371/journal.ppat.1008704⟩ PLoS pathogens, vol 16, iss 7 |
| ISSN: | 1553-7366 1553-7374 |
| DOI: | 10.1371/journal.ppat.1008704⟩ |
| Popis: | Uncertainty about the importance of influenza transmission by airborne droplet nuclei generates controversy for infection control. Human challenge-transmission studies have been supported as the most promising approach to fill this knowledge gap. Healthy, seronegative volunteer ‘Donors’ (n = 52) were randomly selected for intranasal challenge with influenza A/Wisconsin/67/2005 (H3N2). ‘Recipients’ randomized to Intervention (IR, n = 40) or Control (CR, n = 35) groups were exposed to Donors for four days. IRs wore face shields and hand sanitized frequently to limit large droplet and contact transmission. One transmitted infection was confirmed by serology in a CR, yielding a secondary attack rate of 2.9% among CR, 0% in IR (p = 0.47 for group difference), and 1.3% overall, significantly less than 16% (p Author summary Understanding the relative importance of influenza modes of transmission informs strategic use of preventive measures to reduce influenza risk in high-risk settings such as hospitals and is important for pandemic preparedness. Given the increasing evidence from epidemiological modelling, exhaled viral aerosol, and aerobiological survival studies supporting a role for airborne transmission and the potential benefit of respirators (and other precautions designed to prevent inhalation of aerosols) versus surgical masks (mainly effective for reducing exposure to large droplets) to protect healthcare workers, more studies are needed to evaluate the extent of risk posed airborne versus contact and large droplet spray transmission modes. New human challenge-transmission studies should be carefully designed to overcome limitations encountered in the current study. The low secondary attack rate reported herein also suggests that the current challenge-transmission model may no longer be a more promising approach to resolving questions about transmission modes than community-based studies employing environmental monitoring and newer, state-of-the-art deep sequencing-based molecular epidemiological methods. |
| Databáze: | OpenAIRE |
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