Signalling pathways involved in the process of mesenchymal stem cells differentiating into hepatocytes

Autor: Xiaosan Su, Jun-Song Ye, N. de Isla, Lei Zhang, Jean-François Stoltz
Přispěvatelé: Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Bioingénierie Moléculaire, Cellulaire et Thérapeutique (BMCT), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2015
Předmět:
Cell- and Tissue-Based Therapy
Review Article
Mesenchymal Stem Cell Transplantation
Fibroblast growth factor
End Stage Liver Disease
03 medical and health sciences
0302 clinical medicine
Epidermal growth factor
medicine
Humans
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
Review Articles
Cell Proliferation
030304 developmental biology
Hepatocyte differentiation
0303 health sciences
Tissue Engineering
biology
Mesenchymal stem cell
Oncostatin M
Cell Differentiation
Mesenchymal Stem Cells
Cell Biology
General Medicine
Hedgehog signaling pathway
3. Good health
Cell biology
Transplantation
Liver
030220 oncology & carcinogenesis
Immunology
Hepatocytes
biology.protein
Hepatocyte growth factor
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Signal Transduction
medicine.drug
Zdroj: Cell Proliferation
Cell Proliferation, Wiley, 2015, 48 (2), pp.157-165. ⟨10.1111/cpr.12165⟩
ISSN: 1365-2184
0960-7722
DOI: 10.1111/cpr.12165
Popis: International audience; End-stage liver disease can be the termination of acute or chronic liver diseases, with manifestations of liver failure; transplantation is currently an effective treatment for these. However, transplantation is severely limited due to the serious lack of donors, expense, graft rejection and requirement of long-term immunosuppression. Mesenchymal stem cells (MSCs) have attracted considerable attention as therapeutic tools as they can be obtained with relative ease and expanded in culture, along with features of self-renewal and multidirectional differentiation. Many scientific groups have sought to use MSCs differentiating into functional hepatocytes to be used in cell transplantation with liver tissue engineering to repair diseased organs. In most of the literature, hepatocyte differentiation refers to use of various additional growth factors and cytokines, such as hepatocyte growth factor (HGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), oncostatin M (OSM) and more, and most are involved in signalling pathway regulation and cell-cell/cell-matrix interactions. Signalling pathways have been shown to play critical roles in embryonic development, tumourigenesis, tumour progression, apoptosis and cell-fate determination. However, mechanisms of MSCs differentiating into hepatocytes, particularly signalling pathways involved, have not as yet been completely illustrated. In this review, we have focused on progress of signalling pathways associated with mesenchymal stem cells differentiating into hepatocytes along with the stepwise differentiation procedure.
Databáze: OpenAIRE
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