Cisplatin‐induced renal effects and thromboxane A 2 receptor blockade
| Autor: | Hans-Georg Eichler, G. T. Dorner, Brigitte Blöchl-Daum, Michael Wolzt, Guenther G. Steger, Gabriela Kornek, Kurt Kletter, H. Pehamberger, P. James, Helene Breiteneder, Markus Müller |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
medicine.medical_specialty Thromboxane Receptors Thromboxane Clinical Biochemistry Urology Renal function Antineoplastic Agents Kidney Biochemistry Renal Circulation Nephrotoxicity Thromboxane A2 chemistry.chemical_compound Internal medicine medicine Humans Aged Renal circulation General Medicine Effective renal plasma flow Middle Aged medicine.anatomical_structure Endocrinology chemistry Decreased glomerular filtration rate Cisplatin Glomerular Filtration Rate |
| Zdroj: | European Journal of Clinical Investigation. 27:836-839 |
| ISSN: | 1365-2362 0014-2972 |
| Popis: | The aim of this study was to evaluate the renal protective effect of linotroban, a thromboxane A2 receptor antagonist, in 25 patients with malignant tumours scheduled for cisplatin therapy. Cisplatin was administered 1 h after the start of a 24-h continuous infusion of linotroban or placebo. Glomerular filtration rate and effective renal plasma flow were measured. Infusions of cisplatin decreased glomerular filtration rate by 17 +/- 25 mL min-1 (P = 0.049 vs. baseline) and effective renal plasma flow by 94 +/- 150 mL min-1 (P = 0.049 vs. baseline) in the placebo group. In the linotroban group a decrease in glomerular filtration rate by 11 +/- 18 mL min-1 (P = 0.050 vs. baseline) and in effective renal plasma flow by 26 +/- 63 mL min-1 (P = 0.2 vs. baseline) was noted. However, no difference was noted between groups in response to treatment. Our findings indicate that linotroban may not be useful for prevention of cisplatin's acute nephrotoxic effects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text