Waldenström's macroglobulinaemia secreting a paraprotein with lupus anticoagulant activity: possible association with gastrointestinal tract disease and malabsorption
| Autor: | J B Houghton, Robert Campbell Tait, S E Farrand, M R Haeney, P K Oogarah |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Malabsorption Lymphangiectasia Gastroenterology Pathology and Forensic Medicine Immunoglobulin lambda-Chains Malabsorption Syndromes Antibody Specificity Internal medicine hemic and lymphatic diseases medicine Humans Phospholipids Gastrointestinal tract Kidney Lupus anticoagulant biology Waldenstrom macroglobulinemia General Medicine Middle Aged medicine.disease medicine.anatomical_structure Immunoglobulin M Lupus Coagulation Inhibitor Immunology biology.protein lipids (amino acids peptides and proteins) Antibody Waldenstrom Macroglobulinemia Lymphangiectasis Intestinal Paraproteins Research Article |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0021-9746 |
| Popis: | A 51 year old man with Waldenstrom's macroglobulinaemia presented with a malabsorptive syndrome related to extensive small bowel lymphangiectasia caused by immunoglobulin accumulation. The patient's plasma had strong lupus anticoagulant activity and the IgM lambda paraprotein displayed specificity for the negatively charged phospholipids phosphatidyl serine and phosphatidyl inositol, as well as the neutral phosphatidic acid. Despite treatment for the macroglobulinaemia the patient died and at necropsy was found to have myocardial ischaemia and segmental infarcts in the spleen and kidney. The coexistence of these relatively rare findings suggests a possible association between Waldenstrom's macroglobulinaemia with gastrointestinal manifestations and paraprotein specificity for phospholipid. |
| Databáze: | OpenAIRE |
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