Chemotherapy as a risk factor for caries and gingivitis in children with acute lymphoblastic leukemia: A retrospective cohort study

Autor: Shayani, Anis, Silva, Pamela, Salinas, Carolina, Gutierrez, Carolina, Monsálvez, Yandolin, Rivera, César, Aravena, Pedro
Rok vydání: 2021
Předmět:
Zdroj: International Journal of Paediatric Dentistry. 32:538-545
ISSN: 1365-263X
0960-7439
DOI: 10.1111/ipd.12932
Popis: Background: Dental and oral anomalies are among the most common long-term side effects of childhood cancer therapy. Aim: to evaluate chemotherapy as a risk factor for caries lesions and gingivitis in children with acute lymphoblastic leukemia (ALL) treated with the ALL IC-BFM 2009 chemotherapy protocol. Design: A retrospective cohort study was designed. Clinical records of 23 pediatric patients with ALL exposed to chemotherapy in the Regional Hospital in Valdivia-Chile] and 46 unexposed patients assessed every 3 months for 24 months were analyzed. Data on gender, age, number of decayed, missing or filled teeth index and the presence of gingivitis were recorded (Mann-Whitney U test and logistic regression analysis, p ≤ 0.05). Results: A significantly greater frequency of gingivitis (69.57%; p < 0.002) and a mean of new caries lesions were observed in children treated with chemotherapy than in the unexposed children (p < 0.01). The chemotherapy protocol presented a relative risk of 2.15 (95% CI = 1.22 - 2.66; p = 0.01) for new caries lesions and 2.29 (95% CI = 1.76 - 3.82; p = 0.002) for gingivitis. Conclusions: the ALL IC-BFM 2009 chemotherapy protocol in patients with ALL is a risk factor for new caries lesions and gingivitis.
Databáze: OpenAIRE
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