Multi-spectral imaging analysis of HSPB1 expression in head and neck squamous cell carcinoma
| Autor: | Paul M. Weinberger, Sunny S. Khichi, Julien A. Norton, Mark A. Merkley, Lana Jackson, William S. Dynan |
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| Rok vydání: | 2011 |
| Předmět: |
Oncology
Male medicine.medical_specialty animal structures HSP27 Heat-Shock Proteins Multi spectral Tertiary care Statistics Nonparametric Internal medicine Biomarkers Tumor Medicine Humans Stage (cooking) neoplasms Heat-Shock Proteins Neoplasm Staging Retrospective Studies Chi-Square Distribution business.industry Spectrum Analysis Retrospective cohort study medicine.disease Head and neck squamous-cell carcinoma Immunohistochemistry Imaging analysis stomatognathic diseases Otorhinolaryngology Head and Neck Neoplasms Protein Expression Analysis Carcinoma Squamous Cell Female business Molecular Chaperones |
| Zdroj: | The Laryngoscope. 120 |
| ISSN: | 1531-4995 |
| Popis: | The objective of this study was to obtain more accurate quantitation of HSPB1 expression in HNSCC using a novel quantitative protein expression analysis system based on multispectral imaging. The study was a retrospective laboratory study of HNSCC patients treated at tertiary care academic medical center. Archival tissue samples from forty seven patients with HNSCC were subjected to immunohistochemistry using primary antibody to HSPB1. Seven of the patients had early stage cancers (TNM stage I/II) and forty patients had advanced stage cancers (TNM stage III/IV). HSPB1 expression was increased in advanced stage versus early stage cancers. Further investigation of HSPB1 as a potential biomarker for HNSCC is warranted. |
| Databáze: | OpenAIRE |
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