| Autor: |
Suraj M. Yusuf, Gavin R. Norton, Vernice R. Peterson, Nico Malan, Monica Gomes, Nonhlanhla Mthembu, Carlos D. Libhaber, Grace Tade, Hamza Bello, Adamu J. Bamaiyi, Keneilwe N. Mmopi, Ferande Peters, Pinhas Sareli, Patrick H. Dessein, Angela J. Woodiwiss |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Hypertension (Dallas, Tex. : 1979). 80(1) |
| ISSN: |
1524-4563 |
| Popis: |
Background: Whether systolic blood pressure (SBP) control in sustained volume-dependent primary hypertension is associated with blunted ANP (atrial natriuretic peptide) relationships with indexes of volume load is unknown. Methods: Systemic hemodynamics (central pressure, echocardiographic aortic velocity and diameter measurements in the outflow tract), circulating ANP concentrations (ELISA assays) and glomerular and tubular function (24-hour urine collections [n=519]) were determined in a community of African ancestry (n=772). Results: As compared with those with a controlled SBP, those with an uncontrolled SBP (n=198) showed lower ANP concentrations ( P P + excretion (FeNa + ; P P P P P P >0.25), cardiac output ( P >0.29), FeNa + ( P >0.77), or glomerular filtration rate ( P >0.47) and ANP concentrations were noted. Furthermore, in those with an uncontrolled SBP, no relationships between ANP concentrations and SVR or Zc were observed ( P >0.34). Conclusions: In a population where primary hypertension is strongly volume-dependent, those with an uncontrolled SBP have an attenuated relationship between ANP and both renal and hemodynamic indexes of volume overload and the vascular effects of ANP. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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