Transungual Delivery of Ciclopirox Is Increased 3–4-Fold by Mechanical Fenestration of Human Nail Plate in an In Vitro Model
| Autor: | Marta Elena Losa Iglesias, Ricardo Becerro de Bengoa Vallejo, Manuel Córdoba Díaz, Damián Córdoba Díaz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Antifungal
medicine.medical_specialty medicine.drug_class lcsh:RS1-441 Pharmaceutical Science 030226 pharmacology & pharmacy Article In vitro model lcsh:Pharmacy and materia medica Clinical study fenestration 030207 dermatology & venereal diseases 03 medical and health sciences Tecnología farmaceútica 0302 clinical medicine medicine onychomycosis topical skin and connective tissue diseases Ciclopirox integumentary system business.industry ciclopirox Nail plate Surgery medicine.anatomical_structure Drug delivery Nail (anatomy) business Fenestration transungual antifungal medicine.drug |
| Zdroj: | E-Prints Complutense. Archivo Institucional de la UCM instname Pharmaceutics Volume 11 Issue 1 Pharmaceutics, Vol 11, Iss 1, p 29 (2019) |
| Popis: | Onychomycosis is a fungal infection of nails that is widespread and difficult to treat because of the impermeable nature of human nails. Topically applied anti-fungal agents cannot penetrate this structure, and treatment regimens often resort to systemic antifungals with concomitant side effects. One recent clinical study suggested that mechanical fenestration of the nail using an intelligent nail drill might be a possible solution to this problem. In this work, an in vitro model of the transungual delivery of antifungal agents is presented, which utilizes real nail tissue and an inline flow system. This system was deployed to measure transungual delivery of ciclopirox and determined that nail fenestration improved drug delivery by 3&ndash 4-fold after 42 days. This study bolsters the argument that nail fenestration should be accepted as a pretreatment for onychomycosis and offers a way of evaluating new drugs or formulations designed to combat this condition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|