Licensing of DNA replication, cancer, pluripotency and differentiation: An interlinked world?
| Autor: | Nikolaos I. Kanellakis, Zoi Lygerou, P. Nikolopoulou, S. Champeris Tsaniras, Ioanna-Eleni Symeonidou, Stavros Taraviras |
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| Jazyk: | angličtina |
| Předmět: |
DNA re-replication
Pluripotent Stem Cells Pluripotency Computational biology Biology DNA replication Development Epigenesis Genetic Neoplasms medicine Animals Humans Transcription factor Cancer Genetics Cell Differentiation Cell Biology Origin specification medicine.disease DNA replication origin Gene Expression Regulation Neoplastic Licensing factor Licensing Neoplastic Stem Cells Developmental Biology |
| Zdroj: | Seminars in Cell & Developmental Biology. :174-180 |
| ISSN: | 1084-9521 |
| DOI: | 10.1016/j.semcdb.2014.03.013 |
| Popis: | Recent findings provide evidence for a functional interplay between DNA replication and the seemingly distinct areas of cancer, development and pluripotency. Protein complexes participating in DNA replication origin licensing are now known to have roles in development, while their deregulation can lead to cancer. Moreover, transcription factors implicated in the maintenance of or reversal to the pluripotent state have links to the pre-replicative machinery. Several studies have shown that overexpression of these factors is associated to cancer. |
| Databáze: | OpenAIRE |
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