Hepatitis B vaccination of immunosuppressed heart transplant recipients with the vaccine Hepa Gene 3 containing pre-S1, pre-S2, and S gene products
| Autor: | A. E. Hemmerling, D. Wagner, R. Stachan-Kunstyr, H. A. Thoma, J. Flik, I. Wagenbreth |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Hepatitis B virus Genes Viral medicine.medical_treatment Immunization Secondary Virus Postoperative Complications Drug Discovery medicine Humans Hepatitis B Vaccines Hepatitis B Antibodies Protein Precursors Genetics (clinical) Immunization Schedule Immunosuppression Therapy Viral Structural Proteins Hepatitis B Surface Antigens business.industry Vaccination Immunosuppression General Medicine Hepatitis B Middle Aged medicine.disease Virology Transplantation Titer Immunization Immunology Molecular Medicine Heart Transplantation Female Viral disease business |
| Zdroj: | The Clinical investigator. 72(5) |
| ISSN: | 0941-0198 |
| Popis: | The antibody response of immunosuppressed heart transplant recipients to vaccination with the hepatitis B (HB) virus vaccine Hepa Gene 3 (HG-3), containing HB virus pre-S1, pre-S2, and S gene products, was examined. Three heart transplant recipients who had been vaccinated preoperatively against HB responded well to the vaccination. Five of 38 patients (13.2%) vaccinated postoperatively before HG-3 vaccination with the second-generation vaccine Gen-H-B-Vax-D (37 without and 1 with detectable anti-HBs response) and 3 of 24 (12.5%) without previous HB vaccination developed protective anti-HBs titers (greater than 10 U/1) after immunization with the HG-3 vaccine. The l low response rate (8/62, 12.9%) found for postoperatively vaccinated patients indicates that heart transplant recipients should be vaccinated against HB before immunosuppressive medication. |
| Databáze: | OpenAIRE |
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