Behavior of hospitalized severe influenza cases according to the outcome variable in Catalonia, Spain, during the 2017–2018 season

Autor: Soldevila, Núria, Acosta, Lesly, Martínez, Ana, Godoy, Pere, Torner, Núria, Rius i Gibert, Maria Cristina, Jané, Mireia, Domínguez Garcia, Angela, Alsedà, Miquel, Álvarez, Josep, Arias, Chiki, Balaña, Pilar Jorgina, Barrabeig, Irene, Camps, Neus, Carol, Mónica, Ferràs, J., Ferrús, G., Follia, Nuria, Bach, Phuoc, Minguell, Sofia, Parrón, Ignacio, Plasència, Elsa, Sala-Farré, M.R., Torra Balcells, Roser, Torres, J., Marcos, María Ángeles, Mosquera, M.M., Vilella Morato, Anna Maria, Antón, Andrés, Pumarola Suñé, Tomàs, Campins Martí, Magda, García, D., Oller Perez-Hita, A., Espejo, E., Freixas, N., Riera Garcia, M., Maraver, E., Mas, D., Pérez, R., Rebull, J., Pou, J., García-Pardo, G., Olona, M., Barcenilla, F., Castellana, D., Navarro Rubio, Gemma, Force, L., Mòdol-Deltell, J.M., Alvarez, A., Torrel, J.M.
Přispěvatelé: Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. ADBD - Anàlisi de Dades Complexes per a les Decisions Empresarials
Rok vydání: 2021
Předmět:
Male
0301 basic medicine
Epidemiology
Pneumònia
Severity of Illness Index
Hospitals -- Ingressos i altes -- Mètodes estadístics
0302 clinical medicine
Medicine
030212 general & internal medicine
Medicaments antivírics
Unitats de cures intensives
Aged
80 and over
Multidisciplinary
biology
Neuraminidase inhibitor
Middle Aged
Intensive Care Units
Matemàtiques i estadística::Estadística aplicada [Àrees temàtiques de la UPC]
Infectious diseases
Female
medicine.medical_specialty
medicine.drug_class
Science
Pneumonia
Viral
030106 microbiology
Neuraminidase
Severe influenza
Antiviral Agents
Article
Grip
03 medical and health sciences
Internal medicine
Influenza
Human
Severity of illness
Humans
Author Correction
Epidemiologia
Aged
Retrospective Studies
business.industry
Retrospective cohort study
Pneumonia
medicine.disease
Influenza
Risk factors
Spain
biology.protein
Observational study
Influenza virus
business
Ciències de la salut [Àrees temàtiques de la UPC]
Zdroj: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Dipòsit Digital de la UB
Universidad de Barcelona
Scientific Reports
ISSN: 2045-2322
DOI: 10.1038/s41598-021-92895-5
Popis: Altres ajuts: Programme of Prevention, Surveillance and Control of Transmissible Diseases (PREVICET); CIBER de Epidemiología y Salud Pública (CIBERESP). Influenza is an important cause of severe illness and death among patients with underlying medical conditions and in the elderly. The aim of this study was to investigate factors associated with ICU admission and death in patients hospitalized with severe laboratory-confirmed influenza during the 2017-2018 season in Catalonia. An observational epidemiological case-to-case study was carried out. Reported cases of severe laboratory-confirmed influenza requiring hospitalization in 2017-2018 influenza season were included. Mixed-effects regression analysis was used to estimate the factors associated with ICU admission and death. A total of 1306 cases of hospitalized severe influenza cases were included, of whom 175 (13.4%) died and 217 (16.6%) were ICU admitted. Age 65-74 years and ≥ 75 years and having ≥ 2 comorbidities were positively associated with death (aOR 3.19; 95%CI 1.19-8.50, aOR 6.95, 95%CI 2.76-1.80 and aOR 1.99; 95%CI 1.12-3.52, respectively). Neuraminidase inhibitor treatment and pneumonia were negatively associated with death. The 65-74 years and ≥ 75 years age groups were negatively associated with ICU admission (aOR 0.41; 95%CI 0.23-0.74 and aOR 0.30; 95%CI 0.17-0.53, respectively). A factor positively associated with ICU admission was neuraminidase inhibitor treatment. Our results support the need to investigate the worst outcomes of hospitalized severe cases, distinguishing between death and ICU admission.
Databáze: OpenAIRE
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