Cerebrospinal fluid neurofilament light levels mark grey matter volume in clinically isolated syndrome suggestive of multiple sclerosis
| Autor: | Maddalena Ruggieri, Damiano Paolicelli, Stefano Zoccolella, Maria Trojano, Mariangela D'Onghia, Franca Di Cuonzo, Claudio Gasperini, Carla Tortorella, Vita Direnzo, Mariangela Mastrapasqua |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Pathology Neurofilament Multiple Sclerosis Grey matter 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Atrophy Neurofilament Proteins Internal medicine medicine Humans Osteopontin Gray Matter Clinically isolated syndrome biology business.industry Multiple sclerosis Middle Aged medicine.disease 030104 developmental biology Endocrinology medicine.anatomical_structure Neurology Brain size biology.protein Female Neurology (clinical) business 030217 neurology & neurosurgery Biomarkers Demyelinating Diseases |
| Zdroj: | Multiple sclerosis (Houndmills, Basingstoke, England). 24(8) |
| ISSN: | 1477-0970 |
| Popis: | Background: Brain atrophy is a known marker of irreversible tissue damage in multiple sclerosis (MS). Cerebrospinal fluid (CSF) osteopontin (OPN) and neurofilament light chain (NF-L) have been proposed as candidate surrogate markers of inflammatory and neurodegenerative processes in MS. Objective: To evaluate the relationship between CSF NF-L and OPN levels and brain grey and white matter volumes in patients with clinically isolated syndrome (CIS) suggestive of MS. Methods: A total of 41 CIS patients and 30 neurological controls (NCs) were included. CSF NF-L and OPN were measured by commercial ELISA. Measures of brain volume (normalized brain volume (NBV), normalized grey matter volume (NGV), peripheral grey matter volume (PGV), normalized white matter volume (WMV), and ventricular volume) were obtained by SIENAX. Corpus callosum index (CCI) was calculated. Brain volumes were categorized into ‘high’ and ‘low’ according to the median value. Results: CSF NF-L and OPN levels were higher in CIS patients in comparison with NCs. CIS patients with ‘low’ TGV, PGV, and TBV showed higher CSF NF-L levels than CIS patients with ‘high’ brain volumes. TGV and PGV correlated inversely with NF-L levels, whereas CCI was inversely related to OPN levels. CSF NF-L was the only independent predictor of TGV and PGV. Conclusion: CSF NF-L tracks mainly grey matter damage in patients with CIS suggestive of MS. |
| Databáze: | OpenAIRE |
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