Early Allograft Dysfunction and Liver Transplant Outcomes: A Single Center Retrospective Study
| Autor: | R.C. Afonso, B.H. Ferraz-Neto, G.E. Felga, P.R. Salvalaggio |
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| Rok vydání: | 2012 |
| Předmět: |
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medicine.medical_specialty Time Factors Bilirubin medicine.medical_treatment Kaplan-Meier Estimate Liver transplantation Single Center Risk Assessment Gastroenterology Liver disease chemistry.chemical_compound Risk Factors Internal medicine Humans Medicine Aspartate Aminotransferases Risk factor Proportional Hazards Models Retrospective Studies Transplantation Chi-Square Distribution business.industry Incidence Incidence (epidemiology) Graft Survival Alanine Transaminase Retrospective cohort study medicine.disease Liver Transplantation Surgery Treatment Outcome chemistry Female Primary Graft Dysfunction business Biomarkers Brazil |
| Zdroj: | Transplantation Proceedings. 44:2449-2451 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2012.08.002 |
| Popis: | Early allograft dysfunction (EAD) had been related to poor transplant outcomes during the early years of liver transplantation. We sought to determine the incidence of EAD at our unit and to evaluate its impact on posttransplant outcomes.This single-center retrospective study included primary deceased donor liver grafts transplanted under the model for end-stage liver disease system. EAD was defined as a peak values of aminotransferase2000 IU/mL during the first week or an international normalized ratio of ≥1.6 and/or bilirubin ≥10 mg/dL at day 7. The main endpoints were patient and graft survivals.Patients with versus without EAD showed similar recipient characteristics. Donors who experienced EAD who comprises 56% of recipients were heavier with larger body mass indices. EAD was an independent risk factor for allograft loss. Most retransplants were performed early due to nonfunction. The primary nonfunction rate among subjects with versus without EAD were 7% and 12% respectively (P.05). Patient survival among those with EAD was 87.4%, while without EAD it was 90% (P = NS) with graft survivals of 81.4% and 88.7% respectively (P.05).Patients with EAD show a significantly higher risk for allograft loss, but with a comparable survival after transplantation. Despite their worse outcomes, it seems that not all of these recipients behave equally. |
| Databáze: | OpenAIRE |
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