Characterization of a novel natural tetracenomycin reveals crucial role of 4-hydroxy group in ribosome binding

Autor:	Vera A. Alferova, Tinashe P. Maviza, Mikhail V. Biryukov, Yuliya V. Zakalyukina, Vladimir I. Polshakov, Petr V. Sergiev, Vladimir A. Korshun, Ilya A. Osterman
Rok vydání:	2023
Předmět:	General Medicine Biochemistry
Zdroj:	Biochimie. 206:150-153
ISSN:	0300-9084
Popis:	The aromatic polyketides tetracenomycins were recently found to be potent inhibitors of protein synthesis. Their binding site is located in a unique locus within the tunnel of the large ribosomal subunit. Here we report the isolation and structure elucidation of a novel natural tetracenomycin congener - O
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b6af4e97125e359d04b3ee71875a92 https://doi.org/10.1016/j.biochi.2022.10.016 Zobrazit plný text záznamu Full Text from ScienceDirect