Patient preferences for treatment: report from a randomised comparison of treatment strategies in early rheumatoid arthritis (BeSt trial)
| Autor: | K. Huub Han, Ben A. C. Dijkmans, P E H Seys, I. Speyer, B. Grillet, Pit J S M Kerstens, Mike H. de Jager, Ferdinand C. Breedveld, Cornelia F Allaart, Jeska K de Vries-Bouwstra, Peter A H M van der Lubbe, Yvonne P M Goekoop-Ruiterman |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Combination therapy Immunology Severity of Illness Index General Biochemistry Genetics and Molecular Biology Drug Administration Schedule law.invention Treatment and control groups Arthritis Rheumatoid Patient satisfaction Rheumatology Randomized controlled trial law Prednisone Internal medicine Severity of illness medicine Immunology and Allergy Humans Infusions Intravenous Glucocorticoids Aged Retrospective Studies Analysis of Variance business.industry Antibodies Monoclonal Retrospective cohort study Middle Aged Infliximab Surgery Extended Report Treatment Outcome Patient Satisfaction Antirheumatic Agents Drug Therapy Combination Female business medicine.drug Follow-Up Studies |
| Zdroj: | Annals of the rheumatic diseases. 66(9) |
| ISSN: | 0003-4967 |
| Popis: | Objectives: To determine treatment preferences among patients with recent onset rheumatoid arthritis participating in a randomized controlled trial comparing four therapeutic strategies. Methods: A questionnaire was sent to all 508 participants of the BeSt study, treated for an average of 2.2 years with either sequential monotherapy (group 1), step-up combination therapy (group 2), initial combination therapy with tapered high-dose prednisone (group 3), or initial combination therapy with infliximab (group 4). Treatment adjustments were made every 3 months to achieve low disease activity (DAS ≤ 2.4). The questionnaire explored patients9 preferences or dislikes for the initial therapy. Results: In total, 440 patients (87%) completed the questionnaire. Despite virtually equal study outcomes at 2 years, more patients in group 4 reported much or very much improvement of general health: 50%, 56%, 46% and 74% in groups 1-4, respectively (overall, P |
| Databáze: | OpenAIRE |
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