Salba-chia (Salvia hispanica L.) in the treatment of overweight and obese patients with type 2 diabetes: A double-blind randomized controlled trial
| Autor: | L. Choleva, Fei Au-Yeung, John L. Sievenpiper, Alison L. Gibbs, Robert G. Josse, C. Brissette, Lea Duvnjak, Alexandra L Jenkins, Hoang Vi Thanh Ho, A. K. Hanna, Richard P. Bazinet, Andreea Zurbau, Elena Jovanovski, Vladimir Vuksan |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Time Factors Waist Diet Reducing Endocrinology Diabetes and Metabolism Medicine (miscellaneous) 030209 endocrinology & metabolism Type 2 diabetes Overweight Gastroenterology Management of obesity 03 medical and health sciences 0302 clinical medicine Double-Blind Method Weight loss Diabetes mellitus Internal medicine Weight Loss Humans Medicine Obesity Salvia Adiposity Caloric Restriction Glycemic Ontario Plants Medicinal 030109 nutrition & dietetics Nutrition and Dietetics business.industry Middle Aged medicine.disease Treatment Outcome Endocrinology Diabetes Mellitus Type 2 Seeds Female medicine.symptom Cardiology and Cardiovascular Medicine business Phytotherapy |
| Zdroj: | Nutrition, Metabolism and Cardiovascular Diseases. 27:138-146 |
| ISSN: | 0939-4753 |
| DOI: | 10.1016/j.numecd.2016.11.124 |
| Popis: | Background and Aim Preliminary findings indicate that consumption of Salba-chia ( Salvia hispanica L.), an ancient seed, improves management of type 2 diabetes and suppresses appetite. The aim of this study was to assesse the effect of Salba-chia on body weight, visceral obesity and obesity-related risk factors in overweight and obese adults with type 2 diabetes. Methods A double-blind, randomized, controlled trial with two parallel groups involved 77 overweight or obese patients with type 2 diabetes (HbA 1c : 6.5–8.0%; BMI: 25–40 kg/m 2 ). Both groups followed a 6-month calorie-restricted diet; one group received 30 g/1000 kcal/day of Salba-chia, the other 36 g/1000 kcal/day of an oat bran-based control. Primary endpoint was change in body weight over 6-months. Secondary endpoints included changes in waist circumference, body composition, glycemic control, C-reactive protein, and obesity-related satiety hormones. Results At 6-months, participants on Salba-chia had lost more weight than those on control (1.9 ± 0.5 kg and 0.3 ± 0.4 kg, respectively; P = 0.020), accompanied by a greater reduction in waist circumference (3.5 ± 0.7 cm and 1.1 ± 0.7 cm, respectively; P = 0.027). C-reactive protein was reduced by 1.1 ± 0.5 mg/L (39 ± 17%) on Salba-chia, compared to 0.2 ± 0.4 mg/L (7 ± 20%) on control ( P = 0.045). Plasma adiponectin on the test intervention increased by 6.5 ± 0.7%, with no change observed on control ( P = 0.022). Conclusions The results of this study, support the beneficial role of Salba-chia seeds in promoting weight loss and improvements of obesity related risk factors, while maintaining good glycemic control. Supplementation of Salba-chia may be a useful dietary addition to conventional therapy in the management of obesity in diabetes. Registration clinicaltrials.gov identifier: NCT01403571 . |
| Databáze: | OpenAIRE |
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