Synthesis and reactivity of novel γ-phosphate modified ATP analogues
| Autor: | Laurent Bonnac, Emma S. Child, Véronique Gouverneur, David J. Mann, Sarah E. Lee, Alexandra Anderson, Lucy M. Elphick |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Kinase Stereochemistry Cyclin-Dependent Kinase 2 Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biological activity Biochemistry Chemical synthesis chemistry.chemical_compound Adenosine Triphosphate Enzyme chemistry Drug Discovery Click chemistry Molecular Medicine Reactivity (chemistry) Azide Phosphorylation Derivatization Protein Kinase Inhibitors Molecular Biology Cyclin-Dependent Kinase Inhibitor p27 |
| Popis: | We hereby present a simple yet novel chemical synthesis of a family of γ-modified ATPs bearing functional groups on the γ-phosphate that are amenable to further derivatization by highly selective chemical manipulations (e.g., click chemistry, Staudinger ligations). A preliminary screen of these compounds as phosphate donors with a typical wild type protein kinase (cdk2) and one of its known substrates p27kip1 is also presented. © 2009 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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