Cutting Edge: Antibody-Mediated TLR7-Dependent Recognition of Viral RNA
| Autor: | Robert W. Finberg, Evelyn A. Kurt-Jones, Melvin Chan, Jennifer P. Wang, Damon R. Asher |
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| Rok vydání: | 2007 |
| Předmět: |
viruses
Plasma Cells Immunology Antigen-Antibody Complex Receptors Fc Biology Coxsackievirus Antibodies Viral Genome Mice Immune system Animals Humans Immunology and Allergy Receptor Mice Knockout Membrane Glycoproteins virus diseases RNA hemic and immune systems Dendritic Cells TLR7 biology.organism_classification Virology Enterovirus B Human Toll-Like Receptor 7 biology.protein Cytokines RNA Viral Antibody Intracellular Signal Transduction |
| Zdroj: | The Journal of Immunology. 178:3363-3367 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.178.6.3363 |
| Popis: | TLR7 recognizes the genome of ssRNA viruses such as Coxsackievirus B. Because TLR7 is expressed in intracellular compartments, viral RNA must be internalized before its recognition by TLR7. In this study, we define plasmacytoid dendritic cells (pDC) as peripheral blood mononuclear immune cells that respond to Coxsackievirus. pDC activation by Coxsackievirus B requires the presence of specific antiviral Abs. We show that Fc receptors mediate the recognition of virus-Ab complexes and that TLR7 is required for human and murine pDC production of cytokines. These data define a pathway by which intracellular TLR7 senses viral RNA and indicate a role for TLRs in association with Abs in sustaining virus-specific responses. |
| Databáze: | OpenAIRE |
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