Mechanisms of increased epithelial lung clearance of DTPA in diffuse fibrosing alveolitis
| Autor: | Sylvie Labrune, Barritault L, Th. Chinet, G. Huchon, Collignon Ma |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pathology medicine.medical_specialty Pulmonary Fibrosis Vital Capacity Epithelium Pulmonary function testing Fibrosis Forced Expiratory Volume medicine Humans Radionuclide Imaging Lung Aerosols medicine.diagnostic_test business.industry Respiratory disease Total Lung Capacity respiratory system medicine.disease Bronchoalveolar lavage medicine.anatomical_structure Mucociliary Clearance Prednisolone Respiratory epithelium Prednisone Pulmonary Diffusing Capacity Technetium Tc 99m Pentetate Pulmonary alveolus business circulatory and respiratory physiology medicine.drug |
| Zdroj: | The European respiratory journal. 7(4) |
| ISSN: | 0903-1936 |
| Popis: | The aim of this study was to elucidate possible mechanisms of increased epithelial lung clearance in diffuse fibrosing alveolitis (DFA). We investigated the relationships between epithelial lung clearance as assessed by the clearance of aerosolized 99mTc-diethylene-triamine-penta-acetic acid (RC-DTPA), luminal alveolitis as assessed by bronchoalveolar lavage, and pulmonary function, in 30 nonsmokers with DFA. In 14 of these patients, RC-DTPA and lung function were determined before and during therapy with prednisolone (0.5 mg.kg-1 daily). RC-DTPA was higher in patients with DFA (4.45 +/- 2.50%.min-1) than in normal subjects (1.18 +/- 0.31%.min-1). RC-DTPA did not correlate with the number of alveolar neutrophils, but correlated positively with the number of alveolar lymphocytes, and negatively with vital capacity (VC). RC-DTPA decreased from 6.1 +/- 2.8 to 3.8 +/- 1.9%.min-1 with prednisolone. RC-DTPA before prednisolone correlated positively with the prednisolone-associated improvement in VC. We conclude that in patient with DFA, RC-DTPA is increased, and decreases but does not return to normal with corticosteroid therapy. Our data suggest that in DFA the increase in RC-DTPA could be related to the recoil-induced stretch of the respiratory epithelium and to alveolar lymphocytic inflammation. |
| Databáze: | OpenAIRE |
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