Effects of dopamine D1 receptor blockade in the prelimbic prefrontal cortex or lateral dorsal striatum on frontostriatal function in Wistar and Spontaneously Hypertensive Rats
| Autor: | Linda P. Dwoskin, Kathleen M. Kantak, David H. Tassin, Jamie M. Gauthier |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Prefrontal Cortex Striatum Motor Activity Neuropsychological Tests Article Executive Function Behavioral Neuroscience chemistry.chemical_compound Cognition Dopamine receptor D1 Reward Species Specificity Dopamine Rats Inbred SHR Task Performance and Analysis medicine Animals Attention deficit hyperactivity disorder Rats Wistar Prefrontal cortex SCH-23390 Receptors Dopamine D1 Cognitive flexibility Benzazepines medicine.disease Corpus Striatum Blockade Disease Models Animal chemistry Attention Deficit Disorder with Hyperactivity Dopamine Antagonists Psychology Neuroscience medicine.drug |
| Zdroj: | Behavioural Brain Research. 268:229-238 |
| ISSN: | 0166-4328 |
| Popis: | Attention Deficit Hyperactivity Disorder (ADHD) is associated with dysfunctional prefrontal and striatal circuitry and dysregulated dopamine neurotransmission. Spontaneously Hypertensive Rats (SHR), a heuristically useful animal model of ADHD, were evaluated against normotensive Wistar (WIS) controls to determine whether dopamine D1 receptor blockade of either prelimbic prefrontal cortex (plPFC) or lateral dorsal striatum (lDST) altered learning functions of both interconnected sites. A strategy set shifting task measured plPFC function (behavioral flexibility/executive function) and a reward devaluation task measured lDST function (habitual responding). Prior to tests, rats received bilateral infusions of SCH 23390 (1.0 μg/side) or vehicle into plPFC or lDST. Following vehicle, SHR exhibited longer lever press reaction times, more trial omissions, and fewer completed trials during the set shift test compared to WIS, indicating slower decision-making and attentional/motivational impairment in SHR. After reward devaluation, vehicle-treated SHR responded less than WIS, indicating relatively less habitual responding in SHR. After SCH 23390 infusions into plPFC, WIS expressed the same behavioral phenotype as vehicle-treated SHR during set shift and reward devaluation tests. In SHR, SCH 23390 infusions into plPFC exacerbated behavioral deficits in the set shift test and maintained the lower rate of responding in the reward devaluation test. SCH 23390 infusions into lDST did not modify set shifting in either strain, but produced lower rates of responding than vehicle infusions after reward devaluation in WIS. This research provides pharmacological evidence for unidirectional interactions between prefrontal and striatal brain regions, which has implications for the neurological basis of ADHD and its treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect