Prognosis of pregnancy-associated breast cancer: A meta-analysis of 30 studies

Autor: Jr, H. A. Azim, Santoro, L., Russell-Edu, W., Pentheroudakis, George, Pavlidis, Nicholas, Peccatori, Fedro A.
Přispěvatelé: Pavlidis, Nicholas [0000-0002-2195-9961], Pentheroudakis, George [0000-0002-6632-2462], Peccatori, Fedro A. [0000-0001-8227-8740]
Rok vydání: 2012
Předmět:
Survival rate
Cancer relapse
Multivariate analysis
Survival
Review
Breast cancer
Pregnancy
Medicine
Overall survival
Relapse
Disease free survival
education.field_of_study
Obstetrics
Hazard ratio
Puerperium
General Medicine
Prognosis
Survival Rate
Tumor microenvironment
Oncology
Meta-analysis
Female
Pregnancy Complications
Neoplastic
Human
medicine.medical_specialty
Disease-free survival
Population
Breast Neoplasms
Cancer mortality
Case-control studies
Disease-Free Survival
Breast cancer during lactation
Information retrieval
Humans
Radiology
Nuclear Medicine and imaging
education
Gynecology
Neoplastic
Cancer prognosis
business.industry
Confidence interval
Case-control study
medicine.disease
Cancer survival
Pregnancy associated breast cancer
Outcome assessment
Pregnancy complications
Case-Control Studies
Cancer patient
Breast neoplasms
business
Zdroj: Cancer treatment reviews
ISSN: 0305-7372
DOI: 10.1016/j.ctrv.2012.06.004
Popis: Background: Pregnancy-associated breast cancer (PABC) is relatively rare with considerable controversy regarding its prognosis. Patients & methods: Two of the authors independently performed a literature search with no date or language restrictions. Eligible studies were control-matched, population-based and hospital-based studies that addressed the outcome of patients diagnosed during pregnancy or 1-year afterwards. The primary and secondary end-points were overall and disease-free survival respectively. Pooling of data was done using the random effect model. Results: 30 studies were included in this meta-analysis (3,628 cases and 37,100 controls). PABC patients had a significantly higher risk of death compared to those with non-pregnancy-related breast cancer (pooled hazard ratio (pHR): 1.44; 95% CI [1.27-1.63]). The same results were encountered on restricting the analysis to HRs of multivariate analyses (pHR: 1.40 [1.17-1.67]). A clearer trend of poorer outcome was seen in those diagnosed postpartum (pHR: 1.84; 95% CI [1.28-2.65]) than those diagnosed during pregnancy (pHR: 1.29; 95% CI [0.74-2.24]). DFS analysis showed a significantly higher risk of relapse associated with PABC as well (pHR: 1.60 [1.19-2.16]). Conclusion: Our results show that PABC is independently associated with poor survival particularly those diagnosed shortly post-partum. This underscores a possible impact of the pregnant breast microenvironment on the biology and consequently the prognosis of these tumors. © 2012 Elsevier Ltd. 38 7 834 842
Databáze: OpenAIRE
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