Significance of serum hepatocyte growth factor levels in patients with hepatocellular carcinoma undergoing hepatic resection
| Autor: | Gar-Yang Chau, Chin-Wen Chi, Wing-Yiu Lui, Yat Pang Chau, Chew-Wun Wu, Anna Fen-Yau Li, Hwa-Li Kao |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Pathology Carcinoma Hepatocellular Hepatic resection medicine.medical_treatment Gastroenterology Internal medicine medicine Biomarkers Tumor Hepatectomy Humans Receptor Proportional Hazards Models business.industry Hepatocyte Growth Factor Liver Neoplasms General Medicine Middle Aged Proto-Oncogene Proteins c-met medicine.disease Prognosis Survival Analysis digestive system diseases Peripheral medicine.anatomical_structure Oncology Hepatocyte Hepatocellular carcinoma Multivariate Analysis Immunohistochemistry Surgery Hepatocyte growth factor business medicine.drug |
| Zdroj: | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 34(3) |
| ISSN: | 1532-2157 |
| Popis: | Hepatocyte growth factor (HGF) is a potent hepatocyte mitogen and may stimulate the proliferation and invasiveness of human hepatocellular carcinoma (HCC) cells through the c-met receptor. This study evaluates the significance of serum HGF levels in patients undergoing HCC resection.The peripheral and portal sera and HCC and non-tumorous tissues of 40 HCC patients, with tumor TNM stage I (n=12), II (n=17), and III (n=11) diseases, who underwent hepatic resection were prospectively collected. Serum HGF levels were determined by enzyme-linked immunosorbent assay. The c-met protein expressions were examined by immunohistochemistry. Median follow-up time was 69 months.The prehepatectomy portal HGF levels (median, 622pg/mL) were significantly higher than peripheral HGF levels (564pg/mL) (P=0.026). The posthepatectomy portal HGF levels (699pg/mL) were significantly higher than prehepatectomy portal HGF levels (P0.001). C-met expression was detected in 87.5% HCC and in 85.0% non-tumorous liver tissues. By Cox multivariate analysis, posthepatectomy portal HGF level699pg/mL (P0.001), multiple tumors (P=0.042), and TNM stages II (P=0.019) and III (P=0.009) were independent factors related with survival. Patients with a posthepatectomy portal HCG level699pg/mL and with a positive c-met expression in HCC tissue have the worst survival.In HCC patients, high peripheral and portal HGF serum levels related with poor prognosis after hepatic resection. Hepatocyte growth factor and c-met receptor can be targets of future HCC postoperative treatment. |
| Databáze: | OpenAIRE |
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